ZSWIM8

ZSWIM8 (Zinc Finger SWIM-Type Containing 8) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.

Full Name

zinc finger SWIM-type containing 8

Function

Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237).
The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237).
Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234).
May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004).

Biological Process

Biological Process positive regulation of miRNA catabolic process Source:UniProtKB2 Publications
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, cytosol