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Mouse Anti-ZSWIM8 Recombinant Antibody (CBWJZ-302) (CBMAB-Z0787-WJ)

This product is a mouse antibody that recognizes ZSWIM8. The antibody CBWJZ-302 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ZSWIM8 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJZ-302
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
zinc finger SWIM-type containing 8
Introduction
ZSWIM8 (Zinc Finger SWIM-Type Containing 8) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.
Entrez Gene ID
Human23053
Mouse268721
Rat361004
UniProt ID
HumanA7E2V4
MouseQ3UHH1
RatD4A5A9
Alternative Names
KIAA0913
Function
Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237).
The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237).
Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234).
May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004).
Biological Process
Biological Process positive regulation of miRNA catabolic process Source:UniProtKB2 Publications
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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