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Mouse Anti-ACMSD Recombinant Antibody (V2-12501) (CBMAB-0991-CN)

This product is a mouse antibody that recognizes ACMSD of human. The antibody 3A9 can be used for immunoassay techniques such as: WB, ELISA.
See all ACMSD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-12501
Antibody Isotype
IgG2b
Application
WB, ELISA

Basic Information

Immunogen
ACMSD (NP_612199, aa. 179-278) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1-5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
aminocarboxymuconate semialdehyde decarboxylase
Introduction
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. The protein converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Entrez Gene ID
130013
UniProt ID
Q8TDX5
Alternative Names
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase; EC 4.1.1.45
Function
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Biological Process
Negative regulation of quinolinate biosynthetic process
Picolinic acid biosynthetic process
Regulation of 'de novo' NAD biosynthetic process from tryptophan
Secondary metabolic process
Tryptophan catabolic process
Cellular Location
Cytosol; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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