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Mouse Anti-ADAMTS10 Recombinant Antibody (V2-179825) (CBMAB-A1188-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all ADAMTS10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179825
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ADAMTS10 Phe26-Gly1102.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 μg/ml
IP25 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-1103

Target

Full Name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10
Introduction
ADAMTS10 belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type a
Entrez Gene ID
81794
UniProt ID
Q9H324
Alternative Names
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 10; ADAM-TS 10; ADAM-TS10; ADAMTS-10; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10;
Function
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
Biological Process
Extracellular matrix organization
Cellular Location
Extracellular matrix
Involvement in disease
Weill-Marchesani syndrome 1 (WMS1): A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.
PTM
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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