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Rabbit Anti-AGER Recombinant Antibody (V2-6093) (CBMAB-0038CQ)

This product is a rabbit antibody that recognizes AGER. The antibody BA0101 can be used for immunoassay techniques such as: WB.
See all AGER antibodies
Published Data
Rabbit Anti-AGER Recombinant Antibody (BA0101) (CBMAB-0038CQ) in WB
Western blot analysis of protein expression in human lung epithelial cells (Calu-3) after siRNA-mediated depletion of TLR4 or AGER. ...View More
Chen, R., Huang, Y., Quan, J., Liu, J., Wang, H., Billiar, T. R., ... & Tang, D. (2020). HMGB1 as a potential biomarker and therapeutic target for severe COVID-19. Heliyon, 6(12), e05672.
Rabbit Anti-AGER Recombinant Antibody (BA0101) (CBMAB-0038CQ) in WB
The levels of RAGE and TLR4 in MSCs exposed to MSCs [−] or indicated cell lines CM for 24 h. The blot was repeated 3 separate times. ...View More
Ryan, D., Koziol, J., & ElShamy, W. M. (2019). Targeting AXL and RAGE to prevent geminin overexpression-induced triple-negative breast cancer metastasis. Scientific reports, 9(1), 1-19.
Rabbit Anti-AGER Recombinant Antibody (BA0101) (CBMAB-0038CQ) in IHC
GemOE tumor cells induce MSCs to express RAGE and CXCR4
(A) The levels of RAGE on the surface of early passage MSCs following exposure to none (−), naïve HME, iG240 or iG257 CM for 24 h. (B-C) adjacent sections from GemOE orthotopic mammary tumor stained with H & E (B) or immunohistochemically stained with geminin (C) or RAGE (D). ...View More
Ananthula, S., Sinha, A., El Gassim, M., Batth, S., Marshall Jr, G. D., Gardner, L. H., ... & ElShamy, W. M. (2016). Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers. Oncotarget, 7(15), 20869.
Rabbit Anti-AGER Recombinant Antibody (BA0101) (CBMAB-0038CQ) in WB
Western blotting analysis demonstrated that HMGB1 and RAGE protein expression levels were upregulated in the infarcted segments of the brains of rats that had undergone CVST. ...View More
Gu, J. J., Chen, J. B., Zhang, J. H., Zhang, H., & Wang, S. S. (2016). Recombinant human soluble thrombomodulin protects against brain injury in a CVST rat model, via downregulation of the HMGB1-RAGE axis. Molecular medicine reports, 14(6), 5217-5222.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
V2-6093
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human RAGE aa 350 to the C-terminus (Cysteine residue)
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Advanced Glycosylation End-Product Specific Receptor
Introduction
RAGE, a multiligand member of the immunoglobulin superfamily of cell surface molecules, interacts with distinct molecules implicated in homeostasis, development, and inflammation, and certain diseases such as diabetes and Alzheimer disease. The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene.
Entrez Gene ID
Human177
Mouse11596
Rat81722
UniProt ID
HumanQ15109
MouseQ62151
RatQ63495
Alternative Names
Advanced Glycosylation End Product-Specific Receptor; RAGE; Receptor For Advanced Glycation End-Products Variant 20; Receptor For Advanced Glycosylation End Products; RAGE Isoform NtRAGE-Delta; RAGE Isoform SRAGE-Delta
Function
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Biological Process
Astrocyte activation
Cell surface receptor signaling pathway
Cellular response to amyloid-beta
Glucose mediated signaling pathway
Induction of positive chemotaxis
Inflammatory response
Innate immune response
Learning or memory
Microglial cell activation
Modulation of age-related behavioral decline
Negative regulation of blood circulation
Negative regulation of connective tissue replacement involved in inflammatory response wound healing
Negative regulation of interleukin-10 production
Negative regulation of long-term synaptic depression
Negative regulation of long-term synaptic potentiation
Neuron projection development
Positive regulation of activated T cell proliferation
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Positive regulation of chemokine production
Positive regulation of dendritic cell differentiation
Positive regulation of endothelin production
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of heterotypic cell-cell adhesion
Positive regulation of interleukin-12 production
Positive regulation of interleukin-1 beta production
Positive regulation of interleukin-6 production
Positive regulation of JNK cascade
Positive regulation of JUN kinase activity
Positive regulation of monocyte chemotactic protein-1 production
Positive regulation of monocyte extravasation
Positive regulation of NF-kappaB transcription factor activity
Positive regulation of NIK/NF-kappaB signaling
Positive regulation of p38MAPK cascade
Positive regulation of protein phosphorylation
Positive regulation of tumor necrosis factor production
Protein localization to membrane
Regulation of CD4-positive, alpha-beta T cell activation
Regulation of DNA binding
Regulation of inflammatory response
Regulation of long-term synaptic potentiation
Regulation of NIK/NF-kappaB signaling
Regulation of p38MAPK cascade
Regulation of spontaneous synaptic transmission
Regulation of synaptic plasticity
Regulation of T cell mediated cytotoxicity
Response to amyloid-beta
Response to hypoxia
Response to wounding
Transcytosis
Transport across blood-brain barrier
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 10: Cell membrane
Topology
Extracellular: 23-342 aa
Helical: 343-363 aa
Cytoplasmic: 364-404 aa

Li, S., Hu, D., Hu, S., Sun, Y., Zhang, Y., Li, H., ... & Wang, D. W. (2020). Association of rs2070600 in advanced glycosylation end‐product specific receptor with prognosis of heart failure. ESC heart failure, 7(6), 3561-3572.

Mamoor, S. (2020). The receptor for advanced glycosylation end products, RAGE (AGER) is differentially expressed in non-small cell lung cancer and associates with patient survival.

Xue, X. X., Lei, H. Q., Zhao, L., Wang, X. Y., Wang, Z., Xie, L. Y., & Jia, J. H. (2020). MiR-185-3p downregulates advanced glycosylation end product receptor expression and improves renal function in diabetic nephropathy mice. Eur Rev Med Pharmacol Sci, 24(9), 5018-5027.

Shen, C. Y., Lu, C. H., Wu, C. H., Li, K. J., Kuo, Y. M., Hsieh, S. C., & Yu, C. L. (2020). The development of Maillard reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) signaling inhibitors as novel therapeutic strategies for patients with age-related diseases. Molecules, 25(23), 5591.

Serveaux-Dancer, M., Jabaudon, M., Creveaux, I., Belville, C., Blondonnet, R., Gross, C., ... & Sapin, V. (2019). Pathological implications of receptor for advanced glycation end-product (AGER) gene polymorphism. Disease markers, 2019.

Yang, Q., Tang, Y., Tang, C., Cong, H., Wang, X., Shen, X., & Ju, S. (2019). Diminished LINC00173 expression induced miR-182-5p accumulation promotes cell proliferation, migration and apoptosis inhibition via AGER/NF-κB pathway in non-small-cell lung cancer. American journal of translational research, 11(7), 4248.

Ghafouri-Fard, S., Noroozi, R., Musavi, M., & Taheri, M. (2019). Association analysis between genomic variants within advanced glycation end product specific receptor (AGER) gene and risk of breast cancer in Iranian women. Heliyon, 5(10), e02542.

Li, P., Tang, Z., Wang, L., & Feng, B. (2017). Glucagon-like peptide-1 analogue liraglutide ameliorates atherogenesis via inhibiting advanced glycation end product-induced receptor for advanced glycosylation end product expression in apolipoprotein-E deficient mice. Molecular medicine reports, 16(3), 3421-3426.

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For research use only. Not intended for any clinical use.

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