Mouse Anti-ARR3 Recombinant Antibody (2D7) (CBMAB-A0498-LY)

Name: Mouse Anti-ARR3 Recombinant Antibody (2D7)
SKU: CBMAB-A0498-LY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-ARR3 Recombinant Antibody (2D7) CBMAB-A0498-LY in IF

Co-labeling of HK2 (red) and ARR3 (green) confirms that the remaining HK2 expression is limited to cone photoreceptors in cKO mice. ...View More

Weh, E., Lutrzykowska, Z., Smith, A., Hager, H., Pawar, M., Wubben, T. J., & Besirli, C. G. (2020). Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress. Cell Death & Disease, 11(6), 422.

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2D7

Application

WB, ELISA, IP

Immunogen

Amino acids 1-359 representing full length Arrestin-C of human origin.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ARR3

Entrez Gene ID

407

UniProt ID

P36575

Alternative Names

ARRX

Function

May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.

Biological Process

G protein-coupled receptor internalization Source: GO_Central
Regulation of protein phosphorylation Source: Ensembl
Signal transduction Source: ProtInc
Visual perception Source: GO_Central

Cellular Location

Photoreceptor inner segment; Photoreceptor outer segment

Involvement in disease

Myopia 26, X-linked, female-limited (MYP26): A form of myopia, a refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. MYP26 is characterized by typical tigroid fundus changes commonly seen in early onset high myopia, and an unusual pattern of X-linked female-limited inheritance.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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