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Mouse Anti-ARR3 Recombinant Antibody (2D7) (CBMAB-A0498-LY)

The product is antibody recognizes ARR3. The antibody 2D7 immunoassay techniques such as: WB, ELISA.
See all ARR3 antibodies
Published Data
Mouse Anti-ARR3 Recombinant Antibody (2D7) CBMAB-A0498-LY in IF
Co-labeling of HK2 (red) and ARR3 (green) confirms that the remaining HK2 expression is limited to cone photoreceptors in cKO mice. ...View More
Weh, E., Lutrzykowska, Z., Smith, A., Hager, H., Pawar, M., Wubben, T. J., & Besirli, C. G. (2020). Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress. Cell Death & Disease, 11(6), 422.

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IP

Basic Information

Immunogen
Amino acids 1-359 representing full length Arrestin-C of human origin.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Arrestin 3
Entrez Gene ID
407
UniProt ID
P36575
Alternative Names
ARRX
Function
May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.
Biological Process
G protein-coupled receptor internalization Source: GO_Central
Regulation of protein phosphorylation Source: Ensembl
Signal transduction Source: ProtInc
Visual perception Source: GO_Central
Cellular Location
Photoreceptor inner segment; Photoreceptor outer segment
Involvement in disease
Myopia 26, X-linked, female-limited (MYP26): A form of myopia, a refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. MYP26 is characterized by typical tigroid fundus changes commonly seen in early onset high myopia, and an unusual pattern of X-linked female-limited inheritance.

He, L., Gooding, S. W., Lewis, E., Felth, L. C., Gaur, A., & Whistler, J. L. (2021). Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice. Neuropsychopharmacology, 1-9.

Hutchinson, J. L., Zhao, X., Hill, R., & Mundell, S. J. (2020). Arrestin-3 differentially regulates platelet GPCR subsets. Platelets, 31(5), 641-645.

Avsar, S. Y., Kapinos, L. E., Schoenenberger, C. A., Schertler, G. F., Mühle, J., Meger, B., ... & Palivan, C. G. (2020). Immobilization of arrestin-3 on different biosensor platforms for evaluating GPCR binding. Physical Chemistry Chemical Physics, 22(41), 24086-24096.

Kook, S., Vishnivetskiy, S. A., Gurevich, V. V., & Gurevich, E. V. (2019). Cleavage of arrestin-3 by caspases attenuates cell death by precluding arrestin-dependent JNK activation. Cellular signalling, 54, 161-169.

Kurt, M. H. (2019). In silico phosphorylation-independent activation of arrestin-3 protein by means of small molecules (Master's thesis, İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü).

Wanka, L., Babilon, S., Kaiser, A., Mörl, K., & Beck-Sickinger, A. G. (2018). Different mode of arrestin-3 binding at the human Y1 and Y2 receptor. Cellular signalling, 50, 58-71.

Chen, Q., Perry, N. A., Vishnivetskiy, S. A., Berndt, S., Gilbert, N. C., Zhuo, Y., ... & Iverson, T. M. (2017). Structural basis of arrestin-3 activation and signaling. Nature communications, 8(1), 1-13.

Zurkovsky, L., Sedaghat, K., Ahmed, M. R., Gurevich, V. V., & Gurevich, E. V. (2017). Arrestin-2 and arrestin-3 differentially modulate locomotor responses and sensitization to amphetamine. Neuropharmacology, 121, 20-29.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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