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Mouse Anti-ATAD1 Recombinant Antibody (S125-10) (CBMAB-A3832-YC)

Provided herein is a Mouse monoclonal antibody against Mammalian ATPase Family, AAA Domain Containing 1. The antibody can be used for immunoassay techniques, such as ICC, IF, IHC, IP, WB.
See all ATAD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S125-10
Antibody Isotype
IgG1
Application
ICC, IF, IHC, WB

Basic Information

Immunogen
Fusion protein amino acids 1-361 (Full length) of mouse Thorase.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IHC1:1,000
IF(ICC)1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-361

Target

Full Name
ATPase Family, AAA Domain Containing 1
Introduction
ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recyclin
Entrez Gene ID
67979
UniProt ID
Q9D5T0
Alternative Names
ATPase Family, AAA Domain Containing 1; Thorase; ATPase Family AAA Domain-Containing Protein 1; EC 3.6.1.3; FNP001; AFDC1;
Function
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043).
Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity).
Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity).
Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).
Biological Process
Extraction of mislocalized protein from mitochondrial outer membrane Source: UniProtKB
Learning Source: UniProtKB
Memory Source: UniProtKB
Negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
Positive regulation of receptor internalization Source: UniProtKB
Protein import into peroxisome membrane Source: Reactome
Regulation of postsynaptic neurotransmitter receptor internalization Source: Ensembl
Cellular Location
Mitochondrion outer membrane; Postsynaptic cell membrane; Peroxisome membrane
Involvement in disease
Hyperekplexia 4 (HKPX4): An autosomal recessive severe neurologic disorder apparent from birth. HKPX4 is characterized by little if any development, hypertonia, early-onset refractory seizures in some patients, and respiratory failure resulting in early death, mostly in the first months of life.
Topology
Mitochondrial intermembrane: 1-15 aa
Helical: 16-32 aa
Cytoplasmic: 33-361 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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