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Mouse Anti-CBLN2 Recombinant Antibody (704323) (CBMAB-C8407-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
704323
Application
WB
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Cerebellin-2 Arg50-Leu224.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB2 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Cerebellin 2 Precursor
Introduction
CBLN2 (Cerebellin 2 Precursor) is a Protein Coding gene. An important paralog of this gene is CBLN1.
Entrez Gene ID
147381
UniProt ID
Q8IUK8
Alternative Names
Cerebellin 2 Precursor; Cerebellin-2;
Function
Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity).
Essential for long-term maintenance but not establishment of excitatory synapses (By similarity).
Biological Process
Maintenance of synapse structure Source: UniProtKB
Positive regulation of synapse assembly Source: Ensembl
Regulation of presynapse assembly Source: Ensembl
Spontaneous synaptic transmission Source: UniProtKB
Synapse organization Source: UniProtKB
Cellular Location
Secreted

Seigneur, E., Wang, J., Dai, J., Polepalli, J., & Südhof, T. C. (2021). Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Molecular Psychiatry, 1-13.

Shibata, M., Pattabiraman, K., Muchnik, S. K., Kaur, N., Morozov, Y. M., Cheng, X., ... & Sestan, N. (2021). Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis. Nature, 598(7881), 489-494.

Sandor, K., Krishnan, S., Agalave, N. M., Krock, E., Salcido, J. V., Fernandez-Zafra, T., ... & Kultima, K. (2018). Spinal injection of newly identified cerebellin-1 and cerebellin-2 peptides induce mechanical hypersensitivity in mice. Neuropeptides, 69, 53-59.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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