Mouse Anti-CDC40 Recombinant Antibody (EG569) (CBMAB-EN688-LY)

Name: Mouse Anti-CDC40 Recombinant Antibody (EG569)
SKU: CBMAB-EN688-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

EG569

Application

WB, IF, IP, ELISA

Immunogen

Amino acids 139-162 within an internal region of Cdc40 of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG3, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cell Division Cycle 40

Introduction

CDC40 (Cell Division Cycle 40) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination. An important paralog of this gene is WDR25.

Entrez Gene ID

Human	51362
Mouse	71713
Rat	361859

UniProt ID

Human	O60508
Mouse	Q9DC48
Rat	F1LTB9

Alternative Names

Cell Division Cycle 40; Cell Division Cycle 40 Homolog; EH-Binding Protein 3; PRP17 Homolog; PRPF17; HPRP17; PRP17;

Function

Required for pre-mRNA splicing as component of the activated spliceosome.

Biological Process

mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: Reactome
mRNA splicing, via spliceosome Source: UniProtKB
RNA export from nucleus Source: Reactome

Cellular Location

Nucleus; Nucleus speckle

Hu, D., Thériault, B. L., Talebian, V., Owen, J., Marcellus, R., & Al-awar, R. (2021). Validating the WD repeat protein CDC40 as a potential therapeutic target for lung cancer.

Zhu, F., Li, H., Ding, F., Guo, H., Mou, H., & Ma, J. (2020). MiR-422a in gastric cancer cells directly targets CDC40 and modulates cell proliferation. American journal of translational research, 12(8), 4693.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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