Rabbit Anti-CDH10 Recombinant Antibody (EG580) (CBMAB-EN701-LY)

The product is antibody recognizes CDH10. The antibody EG580 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:40000.
See all CDH10 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG580

Antibody Isotype

IgG

Application

IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human CDH10.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cadherin 10

Introduction

CDH10 (Cadherin 10) is a Protein Coding gene. Diseases associated with CDH10 include Lung Squamous Cell Carcinoma. Among its related pathways are ERK Signaling and S-1P Stimulated Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH6.

Entrez Gene ID

Human	1008
Mouse	320873

UniProt ID

Human	Q9Y6N8
Mouse	P70408

Alternative Names

Cadherin 10; T2-Cadherin; Cadherin 10, Type 2 (T2-Cadherin); Cadherin 10 Type 2; Cadherin-10;

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell-cell adhesion Source: UniProtKB
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 55-613
Helical: 614-634
Cytoplasmic: 635-788

References

Casciello, F., Al-Ejeh, F., Miranda, M., Kelly, G., Baxter, E., Windloch, K., ... & Lee, J. S. (2020). G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome. Theranostics, 10(10), 4515.

Zhang, Y., Cheng, Z., Yan, W. Z., Liu, S. F., Hu, C. H., & Zhang, G. S. (2018). Molecular characterization and therapeutic reaction to dasatinib in a CML patient harboring a novel e8a2 BCR-ABL1 transcript with a somatic mutation in TP53BP2 and cadherin-10 genes. Leukemia & lymphoma, 59(1), 233-236.

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A. P., Yonescu, R., ... & Harada, S. (2017). Alterations of type II classical cadherin, cadherin‐10 (CDH10), is associated with pancreatic ductal adenocarcinomas. Genes, Chromosomes and Cancer, 56(5), 427-435.

Smith, K. R., Jones, K. A., Kopeikina, K. J., Burette, A. C., Copits, B. A., Yoon, S., ... & Penzes, P. (2017). Cadherin-10 maintains excitatory/inhibitory ratio through interactions with synaptic proteins. Journal of Neuroscience, 37(46), 11127-11139.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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