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Mouse Anti-CDKL4 Recombinant Antibody (CBYY-C1800) (CBMAB-C3238-YY)

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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1800
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IHC

Basic Information

Immunogen
CDKL4 (196 a.a. ~ 295 a.a) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin Dependent Kinase Like 4
Entrez Gene ID
UniProt ID
Biological Process
Protein phosphorylation Source: GO_Central
Cellular Location
Cytoplasm
More Infomation

Li, Q., Chen, L., Ma, Y. F., Jian, X. E., Ji, J. H., You, W. W., & Zhao, P. L. (2021). Development of pteridin-7 (8H)-one analogues as highly potent cyclin-dependent kinase 4/6 inhibitors: Synthesis, structure-activity relationship, and biological activity. Bioorganic Chemistry, 116, 105324.

Assi, T., Kattan, J., Rassy, E., Nassereddine, H., Farhat, F., Honore, C., ... & Mir, O. (2020). Targeting CDK4 (cyclin-dependent kinase) amplification in liposarcoma: A comprehensive review. Critical Reviews in Oncology/Hematology, 153, 103029.

Wang, P. F., Qiu, H. Y., He, Y., & Zhu, H. L. (2020). Cyclin-dependent kinase 4/6 inhibitors for cancer therapy: a patent review (2015–2019). Expert Opinion on Therapeutic Patents, 30(10), 795-805.

Occhipinti, G., Romagnoli, E., Santoni, M., Cimadamore, A., Sorgentoni, G., Cecati, M., ... & Piva, F. (2020). Sequential or concomitant inhibition of cyclin-dependent kinase 4/6 before mTOR pathway in hormone-positive HER2 negative breast cancer: biological insights and clinical implications. Frontiers in genetics, 11, 349.

Guiley, K. Z., Stevenson, J. W., Lou, K., Barkovich, K. J., Kumarasamy, V., Wijeratne, T. U., ... & Rubin, S. M. (2019). p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366(6471).

Vemu, B., Nauman, M. C., Veenstra, J. P., & Johnson, J. J. (2019). Structure activity relationship of xanthones for inhibition of Cyclin Dependent Kinase 4 from mangosteen (Garcinia mangostana L.). International journal of nutrition, 4(2), 38.

Zhou, Y., Shen, J. K., Yu, Z., Hornicek, F. J., Kan, Q., & Duan, Z. (2018). Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(5), 1573-1582.

Li, X., Seebacher, N. A., Garbutt, C., Ma, H., Gao, P., Xiao, T., ... & Duan, Z. (2018). Inhibition of cyclin-dependent kinase 4 as a potential therapeutic strategy for treatment of synovial sarcoma. Cell death & disease, 9(5), 1-14.

Thill, M., & Schmidt, M. (2018). Management of adverse events during cyclin-dependent kinase 4/6 (CDK4/6) inhibitor-based treatment in breast cancer. Therapeutic advances in medical oncology, 10, 1758835918793326.

Tripathy, D., Bardia, A., & Sellers, W. R. (2017). Ribociclib (LEE011): mechanism of action and clinical impact of this selective cyclin-dependent kinase 4/6 inhibitor in various solid tumors. Clinical Cancer Research, 23(13), 3251-3262.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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