Mouse Anti-CLDN14 Recombinant Antibody (CBCNC-007) (V2LY-1206-LY8)

Name: Mouse Anti-CLDN14 Recombinant Antibody (CBCNC-007)
SKU: V2LY-1206-LY8
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNC-007

Application

ELISA, IP

Immunogen

CLDN14 (29 a.a. ~ 81 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

claudin 14

Entrez Gene ID

23562

UniProt ID

O95500

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Biological Process

Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Protein-containing complex assembly Source: ProtInc

Cellular Location

Cell membrane; Tight junction

Involvement in disease

Deafness, autosomal recessive, 29 (DFNB29):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Topology

Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-115
Helical: 116-136
Extracellular: 137-162
Helical: 163-183
Cytoplasmic: 184-239

van Megen, W., Beggs, M., An, S. W., Ferreira, P., Lee, J., Wolf, M., ... & Dimke, H. (2022). Gentamicin Inhibits Ca2+ Channel TPRV5 and Induces Calciuresis Independent of the Calcium-Sensing Receptor-Claudin-14 Pathway. Journal of the American Society of Nephrology.

Frische, S., Alexander, R. T., Ferreira, P., Tan, R. S. G., Wang, W., Svenningsen, P., ... & Dimke, H. (2021). Localization and regulation of claudin-14 in experimental models of hypercalcemia. American Journal of Physiology-Renal Physiology, 320(1), F74-F86.

Lee, J. J., Alzamil, J., Rehman, S., Pan, W., Dimke, H., & Alexander, R. T. (2021). Activation of the calcium sensing receptor increases claudin‐14 expression via a PLC‐p38‐Sp1 pathway. The FASEB Journal, 35(11), e21982.

Ferreira, P. G., van Megen, W. H., Tan, R., Lee, C. H., Svenningsen, P., Alexander, R. T., & Dimke, H. (2021). Renal claudin-14 expression is not required for regulating Mg2+ balance in mice. American Journal of Physiology-Renal Physiology, 320(5), F897-F907.

Cai, M., Shao, J., Wang, Y., Yung, B., Li, J. N., Zhang, H. H., ... & Yao, D. B. (2021). Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury. Chinese Journal of Traumatology.

Kitano, T., Kitajiri, S. I., Nishio, S. Y., & Usami, S. I. (2019). Detailed clinical features of deafness caused by a claudin-14 variant. International journal of molecular sciences, 20(18), 4579.

Shiraiwa, Y., Daikoku, E., Saito, M., Yamashita, Y., Abe, T., Ono, F., & Kubota, T. (2018). Measurements of ionic concentrations along with endocochlear potential in wild-type and claudin 14 knockout mice. Auris Nasus Larynx, 45(3), 421-426.

Arcidiacono, T., Simonini, M., Lanzani, C., Citterio, L., Salvi, E., Barlassina, C., ... & Vezzoli, G. (2018). Claudin-14 gene polymorphisms and urine calcium excretion. Clinical Journal of the American Society of Nephrology, 13(10), 1542-1549.

Ure, M. E., Heydari, E., Pan, W., Ramesh, A., Rehman, S., Morgan, C., ... & Alexander, R. T. (2017). A variant in a cis‐regulatory element enhances claudin‐14 expression and is associated with pediatric‐onset hypercalciuria and kidney stones. Human mutation, 38(6), 649-657.

Corre, T., Olinger, E., Harris, S. E., Traglia, M., Ulivi, S., Lenarduzzi, S., ... & Devuyst, O. (2017). Common variants in CLDN14 are associated with differential excretion of magnesium over calcium in urine. Pflügers Archiv-European Journal of Physiology, 469(1), 91-103.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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