Mouse Anti-COPD Recombinant Antibody (CBWJC-2956) (V2LY-1206-LY758)

Name: Mouse Anti-COPD Recombinant Antibody (CBWJC-2956)
SKU: V2LY-1206-LY758
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-2956

Application

WB, IF, IHC-P

Immunogen

Recombinant protein within the center region of human COPD.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:3,000
IF(ICC)	1:100-1:1,000
IHC-P	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Entrez Gene ID

Human

260431

UniProt ID

Human	P48444
Mouse	Q5XJY5

Function

Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
Golgi localization Source: GO_Central
Intracellular protein transport Source: ProtInc
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central

Cellular Location

Golgi apparatus membrane; Cytoplasm; COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.

Involvement in disease

Short stature, rhizomelic, with microcephaly, micrognathia, and developmental delay (SRMMD):
The disease is caused by variants affecting the gene represented in this entry. the skeletal phenotype, that characterizes this disorder, may be due to defective type I collagen transport and reduction of collagen secretion. A disorder characterized by facial dysmorphism, severe micrognathia, microcephaly, rhizomelic short stature, and mild developmental delay.

Szalontai, K., Gémes, N., Furák, J., Varga, T., Neuperger, P., Balog, J. Á., ... & Szebeni, G. J. (2021). Chronic obstructive pulmonary disease: epidemiology, biomarkers, and paving the way to lung cancer. Journal of Clinical Medicine, 10(13), 2889.

Ahmed, E., Fieldes, M., Mianné, J., Bourguignon, C., Nasri, A., Vachier, I., ... & De Vos, J. (2021). Generation of four severe early-onset chronic obstructive pulmonary disease (COPD) patient-derived induced pluripotent stem cell lines from peripheral blood mononuclear cells. Stem Cell Research, 56, 102550.

Brandsma, C. A., Van den Berge, M., Hackett, T. L., Brusselle, G., & Timens, W. (2020). Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine. The Journal of pathology, 250(5), 624-635.

Borràs-Santos, A., Garcia-Aymerich, J., Soler-Cataluña, J. J., Giménez, L. V., Guiral, J. G., Chiaradía, D. R., ... & Cosío, B. G. (2019). Determinants of the Appearance and Progression of Early-Onset Chronic Obstructive Pulmonary Disease in Young Adults. A Case–Control Study With Follow-Up. Archivos de Bronconeumología (English Edition), 55(6), 312-318.

Ejike, C. O., Dransfield, M. T., Hansel, N. N., Putcha, N., Raju, S., Martinez, C. H., & Han, M. K. (2019). Chronic obstructive pulmonary disease in America’s black population. American journal of respiratory and critical care medicine, 200(4), 423-430.

Petersen, H., Sood, A., Polverino, F., Owen, C. A., Pinto-Plata, V., Celli, B. R., & Tesfaigzi, Y. (2018). The course of lung function in middle-aged heavy smokers: incidence and time to early onset of chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 198(11), 1449-1451.

Prokopenko, D., Sakornsakolpat, P., Fier, H. L., Qiao, D., Parker, M. M., McDonald, M. L. N., ... & Cho, M. H. (2018). Whole-genome sequencing in severe chronic obstructive pulmonary disease. American journal of respiratory cell and molecular biology, 59(5), 614-622.

Qiao, D., Ameli, A., Prokopenko, D., Chen, H., Kho, A. T., Parker, M. M., ... & Cho, M. H. (2018). Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Human molecular genetics, 27(21), 3801-3812.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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