Mouse Anti-CYFIP2 Recombinant Antibody (4G6) (V2LY-0125-LY874)

Name: Mouse Anti-CYFIP2 Recombinant Antibody (4G6)
SKU: V2LY-0125-LY874
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4G6

Application

ELISA, WB

Immunogen

CYFIP2 (733-820aa) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

cytoplasmic FMR1 interacting protein 2

Entrez Gene ID

26999

UniProt ID

Q96F07

Function

Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).

Biological Process

Activation of cysteine-type endopeptidase activity Source: BHF-UCL
Apoptotic process Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell morphogenesis Source: GO_Central
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Positive regulation of proteolysis Source: BHF-UCL
Regulation of actin filament polymerization Source: InterPro
Vascular endothelial growth factor receptor signaling pathway Source: Reactome

Cellular Location

Cytoplasm; Nucleus; Perinuclear region; Synaptosome. Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118).

Involvement in disease

Developmental and epileptic encephalopathy 65 (DEE65):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE65 is an autosomal dominant form characterized by onset of intractable seizures usually in the first 6 months of life and severe to profound psychomotor developmental delay.

Manigandan, S., & Yun, J. W. (2022). Loss of cytoplasmic FMR1‐interacting protein 2 (CYFIP2) induces browning in 3T3‐L1 adipocytes via repression of GABA‐BR and activation of mTORC1. Journal of Cellular Biochemistry.

Chaya, T., Ishikane, H., Varner, L. R., Sugita, Y., Maeda, Y., Tsutsumi, R., ... & Furukawa, T. (2022). Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity. Human molecular genetics, 31(4), 535-547.

Lee, Y., Zhang, Y., Kang, H., Bang, G., Kim, Y., Kang, H. R., ... & Han, K. (2020). Epilepsy-and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Biochemical and biophysical research communications, 529(1), 1-6.

Zweier, M., Begemann, A., McWalter, K., Cho, M. T., Abela, L., Banka, S., ... & Rauch, A. (2019). Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures. European Journal of Human Genetics, 27(5), 747-759.

Zhang, Y., Lee, Y., & Han, K. (2019). Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy. BMB reports, 52(5), 304.

Zhang, Y., Kang, H. R., & Han, K. (2019). Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus. Animal cells and systems, 23(6), 380-383.

Zhang, Y., Kang, H., Lee, Y., Kim, Y., Lee, B., Kim, J. Y., ... & Han, K. (2019). Smaller body size, early postnatal lethality, and cortical extracellular matrix-related gene expression changes of Cyfip2-null embryonic mice. Frontiers in molecular neuroscience, 11, 482.

Cioni, J. M., Wong, H. H. W., Bressan, D., Kodama, L., Harris, W. A., & Holt, C. E. (2018). Axon-axon interactions regulate topographic optic tract sorting via CYFIP2-dependent WAVE complex function. Neuron, 97(5), 1078-1093.

Kirkpatrick, S. L., Goldberg, L. R., Yazdani, N., Babbs, R. K., Wu, J., Reed, E. R., ... & Bryant, C. D. (2017). Cytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eating. Biological psychiatry, 81(9), 757-769.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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