Mouse Anti-DCDC2 Recombinant Antibody (D0339) (V2LY-0125-LY1180)

Name: Mouse Anti-DCDC2 Recombinant Antibody (D0339)
SKU: V2LY-0125-LY1180
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-DCDC2 Recombinant Antibody (D0339) (V2LY-0125-LY1180) in IHC

Immunostaining of HES4 and DCDC2 in the PCW 9 pancreas. Scale bar, 50μm. Images shown are representatives of more than three samples from three independent experiments. ...View More

Ma, Z., Zhang, X., Zhong, W., Yi, H., Chen, X., Zhao, Y., ... & Xu, T. (2023). Deciphering early human pancreas development at the single-cell level. Nature Communications, 14(1), 5354. Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

D0339

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Amino acids 331-476 mapping at the C-terminus of human DCDC2.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
IHC-P	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

DOUBLECORTIN DOMAIN CONTAINING 2

Entrez Gene ID

51473

UniProt ID

Q9UHG0

Function

Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784).

May be involved in neuronal migration during development of the cerebral neocortex (By similarity).

Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779).

Biological Process

Cellular defense response Source: ProtInc
Cilium assembly Source: UniProtKB
Dendrite morphogenesis Source: GO_Central
Intracellular signal transduction Source: InterPro
Neuron migration Source: UniProtKB
Positive regulation of smoothened signaling pathway Source: GO_Central
Regulation of cilium assembly Source: UniProtKB
Regulation of Wnt signaling pathway Source: UniProtKB
Sensory perception of sound Source: UniProtKB

Cellular Location

Cilium axoneme; Cytoskeleton; Cilium; Kinocilium. Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.

Involvement in disease

Dyslexia 2 (DYX2):
A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability.
Nephronophthisis 19 (NPHP19):
A form of nephronophthisis, an autosomal recessive disorder characterized by chronic tubulointerstitial nephritis resulting in end-stage renal disease. NPHP19 patients also manifest hepatosplenomegaly, hepatic fibrosis, destruction of the bile ducts, focal bile ductal proliferation, ductal plate malformation, and cholestasis.
Deafness, autosomal recessive, 66 (DFNB66):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Sclerosing cholangitis, neonatal (NSC):
An autosomal recessive form of liver disease with onset in infancy. Affected infants have jaundice, cholestasis, acholic stools, and progressive liver dysfunction resulting in fibrosis and cirrhosis. Cholangiography shows patent biliary ducts, but there are bile duct irregularities.

Syryn, H., Hoorens, A., Grammatikopoulos, T., Deheragoda, M., Symoens, S., Vande Velde, S., ... & De Bruyne, R. (2021). Two cases of DCDC2‐related neonatal sclerosing cholangitis with developmental delay and literature review. Clinical Genetics, 100(4), 447-452.

Perani, D., Scifo, P., Cicchini, G. M., Rosa, P. D., Banfi, C., Mascheretti, S., ... & Morrone, M. C. (2021). White matter deficits correlate with visual motion perception impairments in dyslexic carriers of the DCDC2 genetic risk variant. Experimental Brain Research, 239(9), 2725-2740.

Gabel, L. A., Voss, K., Johnson, E., Lindström, E. R., Truong, D. T., Murray, E. M., ... & Gruen, J. R. (2021). Identifying Dyslexia: Link between Maze Learning and Dyslexia Susceptibility Gene, DCDC2, in Young Children. Developmental Neuroscience, 43(2), 116-133.

Vogel, G. F., Maurer, E., Entenmann, A., Straub, S., Knisely, A. S., Janecke, A. R., & Müller, T. (2020). Co-existence of ABCB11 and DCDC2 disease: Infantile cholestasis requires both next-generation sequencing and clinical-histopathologic correlation. European Journal of Human Genetics, 28(6), 840-844.

Riva, V., Mozzi, A., Forni, D., Trezzi, V., Giorda, R., Riva, S., ... & Mascheretti, S. (2019). The influence of DCDC2 risk genetic variants on reading: Testing main and haplotypic effects. Neuropsychologia, 130, 52-58.

Rendall, A. R., Perrino, P. A., LoTurco, J. J., & Fitch, R. H. (2019). Evaluation of visual motion perception ability in mice with knockout of the dyslexia candidate susceptibility gene Dcdc2. Genes, Brain and Behavior, 18(5), e12450.

DeMille, M. M., Tang, K., Mehta, C. M., Geissler, C., Malins, J. G., Powers, N. R., ... & Gruen, J. R. (2018). Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages. Proceedings of the National Academy of Sciences, 115(19), 4951-4956.

Li, J. Q., Lu, Y., Qiu, Y. L., & Wang, J. S. (2018). Neonatal sclerosing cholangitis caused by DCDC2 variations in two siblings and literature review. Zhonghua er ke za zhi= Chinese Journal of Pediatrics, 56(8), 623-627.

Scerri, T. S., Macpherson, E., Martinelli, A., Wa, W. C., Monaco, A. P., Stein, J., ... & Paracchini, S. (2017). The DCDC2 deletion is not a risk factor for dyslexia. Translational psychiatry, 7(7), e1182-e1182.

Chen, Y., Zhao, H., Zhang, Y. X., & Zuo, P. X. (2017). DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children. Neural regeneration research, 12(2), 259.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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