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Mouse Anti-FGFBP1 Recombinant Antibody (CBXF-2165) (CBMAB-F1608-CQ)

This product is a mouse antibody that recognizes FGFBP1. The antibody CBXF-2165 can be used for immunoassay techniques such as: WB.
See all FGFBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2165
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant FGF-BP
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor Binding Protein 1
Introduction
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.
Entrez Gene ID
9982
UniProt ID
Q14512
Alternative Names
Fibroblast Growth Factor Binding Protein 1; 17 KDa Heparin-Binding Growth Factor-Binding Protein; 17 KDa HBGF-Binding Protein; FGF-Binding Protein 1; FGF-BP1; FGFBP-1;
Research Area
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Biological Process
Cell-cell signaling Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Extracellular space; Cell membrane. Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

Gasparini, G. (2022). Cancer-Glia interaction in perineural invasion in pancreatic cancer: identification of FGF-BP1 as a molecular target.

Al-Sharif, M., Radwan, H., Hendam, B., & Ateya, A. (2022). DNA polymorphisms of FGFBP1, leptin, κ-casein, and αs1-casein genes and their association with reproductive performance in dromedary she-camels. Theriogenology, 178, 18-29.

Wang, F., Luo, M., Qu, H., & Cheng, Y. (2021). BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1. FEBS open bio, 11(5), 1497-1503.

Chen, X., Miao, M., Zhou, M., Chen, J., Li, D., Zhang, L., ... & Fan, X. (2021). Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell death & disease, 12(8), 1-14.

Zhang, Z., Qin, Y., Ji, S., Xu, W., Liu, M., Hu, Q., ... & Xu, X. (2021). FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer. Acta Biochimica et Biophysica Sinica, 53(8), 997-1008.

Chen, J., Liu, Q. M., Du, P. C., Ning, D., Mo, J., Zhu, H. D., ... & Jiang, L. (2020). Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway. American journal of cancer research, 10(2), 662.

Cottarelli, A., Corada, M., Beznoussenko, G. V., Mironov, A. A., Globisch, M. A., Biswas, S., ... & Dejana, E. (2020). Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development, 147(16), dev185140.

Zhao, L., Cao, X., Li, L., Wang, X., Wang, Q., Jiang, S., ... & Lai, E. Y. (2020). Acute kidney injury sensitizes the brain vasculature to Ang II (angiotensin II) constriction via FGFBP1 (fibroblast growth factor binding protein 1). Hypertension, 76(6), 1924-1934.

Zhang, W., Zhou, Y., Li, C., Xu, S., Li, M., Liu, W., ... & Wang, H. (2020). The expression and prognostic value of FGF2, FGFR3, and FGFBP1 in esophageal squamous cell carcinoma. Analytical Cellular Pathology, 2020.

Zhang, Z., Liu, M., Hu, Q., Xu, W., Liu, W., Sun, Q., ... & Qin, Y. (2019). FGFBP1, a downstream target of the FBW7/c-Myc axis, promotes cell proliferation and migration in pancreatic cancer. Amer

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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