Mouse Anti-FGFBP1 Recombinant Antibody (CBXF-2165) (CBMAB-F1608-CQ)

Name: Mouse Anti-FGFBP1 Recombinant Antibody (CBXF-2165)
SKU: CBMAB-F1608-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2165

Application

WB, ELISA

Immunogen

Full length recombinant human FGF-BP.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor Binding Protein 1

Introduction

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.

Entrez Gene ID

9982

UniProt ID

Q14512

Alternative Names

Fibroblast Growth Factor Binding Protein 1; 17 KDa Heparin-Binding Growth Factor-Binding Protein; 17 KDa HBGF-Binding Protein; FGF-Binding Protein 1; FGF-BP1; FGFBP-1;

Research Area

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

Biological Process

Cell-cell signaling Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Extracellular space; Cell membrane. Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

Gasparini, G. (2022). Cancer-Glia interaction in perineural invasion in pancreatic cancer: identification of FGF-BP1 as a molecular target.

Al-Sharif, M., Radwan, H., Hendam, B., & Ateya, A. (2022). DNA polymorphisms of FGFBP1, leptin, κ-casein, and αs1-casein genes and their association with reproductive performance in dromedary she-camels. Theriogenology, 178, 18-29.

Wang, F., Luo, M., Qu, H., & Cheng, Y. (2021). BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1. FEBS open bio, 11(5), 1497-1503.

Chen, X., Miao, M., Zhou, M., Chen, J., Li, D., Zhang, L., ... & Fan, X. (2021). Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell death & disease, 12(8), 1-14.

Zhang, Z., Qin, Y., Ji, S., Xu, W., Liu, M., Hu, Q., ... & Xu, X. (2021). FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer. Acta Biochimica et Biophysica Sinica, 53(8), 997-1008.

Chen, J., Liu, Q. M., Du, P. C., Ning, D., Mo, J., Zhu, H. D., ... & Jiang, L. (2020). Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway. American journal of cancer research, 10(2), 662.

Cottarelli, A., Corada, M., Beznoussenko, G. V., Mironov, A. A., Globisch, M. A., Biswas, S., ... & Dejana, E. (2020). Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development, 147(16), dev185140.

Zhao, L., Cao, X., Li, L., Wang, X., Wang, Q., Jiang, S., ... & Lai, E. Y. (2020). Acute kidney injury sensitizes the brain vasculature to Ang II (angiotensin II) constriction via FGFBP1 (fibroblast growth factor binding protein 1). Hypertension, 76(6), 1924-1934.

Zhang, W., Zhou, Y., Li, C., Xu, S., Li, M., Liu, W., ... & Wang, H. (2020). The expression and prognostic value of FGF2, FGFR3, and FGFBP1 in esophageal squamous cell carcinoma. Analytical Cellular Pathology, 2020.

Zhang, Z., Liu, M., Hu, Q., Xu, W., Liu, W., Sun, Q., ... & Qin, Y. (2019). FGFBP1, a downstream target of the FBW7/c-Myc axis, promotes cell proliferation and migration in pancreatic cancer. Amer

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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