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Mouse Anti-GJB4 Recombinant Antibody (CBFYH-0366) (CBMAB-H1236-FY)

This product is mouse antibody that recognizes GJB4. The antibody CBFYH-0366 can be used for immunoassay techniques such as: ELISA, WB.
See all GJB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0366
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
gap junction protein, beta 4, 30.3kDa
Introduction
This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment.
Entrez Gene ID
127534
UniProt ID
Q9NTQ9
Alternative Names
Gap Junction Protein Beta 4; Gap Junction Protein, Beta 4, 30.3kDa; Connexin 30.3; CX30.3; Gap Junction Protein, Beta 4 (Connexin 30.3); Gap Junction Protein, Beta 4
Function
Structural component of gap junctions (By similarity).

Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).

Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).
Biological Process
Cell-cell signaling Source: UniProtKB
Gap junction-mediated intercellular transport Source: UniProtKB
Olfactory behavior Source: Ensembl
Sensory perception of smell Source: Ensembl
Cellular Location
Cell membrane; Gap junction. Colocalizes with GJB2 at gap junction plaques in the cochlea.
Involvement in disease
Erythrokeratodermia variabilis et progressiva 2 (EKVP2):
A form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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