Rabbit Anti-GNL1 Recombinant Antibody (EG1342) (CBMAB-EN1620-LY)

The product is antibody recognizes GNL1. The antibody EG1342 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all GNL1 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1342

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GNL1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein nucleolar 1

Introduction

The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C.

Entrez Gene ID

Human	2794
Mouse	14670
Rat	309593

UniProt ID

Human	P36915
Mouse	P36916
Rat	Q6MG06

Alternative Names

HSR1

Function

Possible regulatory or functional link with the histocompatibility cluster.

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
Signal transduction Source: UniProtKB
T cell mediated immunity Source: UniProtKB

Cellular Location

Extracellular space; Nucleus

References

Turcotte, M. A., Garant, J. M., Cossette-Roberge, H., & Perreault, J. P. (2021). Guanine Nucleotide-Binding Protein-Like 1 (GNL1) binds RNA G-quadruplex structures in genes associated with Parkinson’s disease. RNA biology, 18(9), 1339-1353.

Krishnan, R., Murugiah, M., Lakshmi, N. P., & Mahalingam, S. (2020). Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 CIP1 signaling cascade. Molecular biology of the cell, 31(26), 2904-2919.

Krishnan, R., Boddapati, N., & Mahalingam, S. (2018). Interplay between human nucleolar GNL1 and RPS20 is critical to modulate cell proliferation. Scientific Reports, 8(1), 1-16.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-GNL1 Recombinant Antibody (CBLG1-3198)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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