Mouse Anti-GNL2 Recombinant Antibody (EG1342) (CBMAB-EN1620-LY)

Name: Mouse Anti-GNL2 Recombinant Antibody (EG1342)
SKU: CBMAB-EN1620-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

EG1342

Application

WB, ELISA, IF, IP

Immunogen

Amino acids 42-225 mapping near the N-terminus of human GNL2.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

guanine nucleotide binding protein-like 2 (nucleolar)

Introduction

The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C.

Entrez Gene ID

Human	29889
Mouse	230737
Rat	362593

UniProt ID

Human	Q13823
Mouse	Q99LH1
Rat	Q4KLJ3

Alternative Names

HSR1

Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity).

May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).

Biological Process

Ribosome biogenesis Source: UniProtKB-KW

Cellular Location

Nucleolus

Wang, Z., Chen, H., Peng, L., He, Y., Wei, J., & Zhang, X. (2023). DNER and GNL2 are differentially m6A methylated in periodontitis in comparison with periodontal health revealed by m6A microarray of human gingival tissue and transcriptomic analysis. Journal of Periodontal Research.

Nakamura, K., Reid, B. M., Chen, A., Chen, Z., Goode, E. L., Permuth, J. B., ... & Karreth, F. A. (2022). Functional analysis of the 1p34. 3 risk locus implicates GNL2 in high-grade serous ovarian cancer. The American Journal of Human Genetics, 109(1), 116-135.

Dong, Y., Cai, Q., Fu, L., Liu, H., Ma, M., & Wu, X. (2021). Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis. BioMed Research International, 2021.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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