Mouse Anti-HPS1 Recombinant Antibody (CBT735) (V2LY-0625-LY3318)

Name: Mouse Anti-HPS1 Recombinant Antibody (CBT735)
SKU: V2LY-0625-LY3318
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-HPS1 Recombinant Antibody (CBT735) (V2LY-0625-LY3318) in WB

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT735

Application

WB, ELISA

Immunogen

Purified recombinant fragment of HPS-1 expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:10,000
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Buffer

BSA, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

HPS1, Biogenesis Of Lysosomal Organelles Complex 3 Subunit 1

Entrez Gene ID

3257

UniProt ID

Q92902

Function

Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).

Biological Process

Lysosome organization Source: ProtInc
Melanosome assembly Source: UniProtKB
Response to stimulus Source: UniProtKB-KW
Vesicle-mediated transport Source: InterPro
Visual perception Source: UniProtKB-KW

Cellular Location

BLOC-3 complex; Cytosol; Lysosome; Cytoplasm; Cytoplasmic vesicle

Involvement in disease

Hermansky-Pudlak syndrome 1 (HPS1):
A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Yu, J., He, X., Wei, A., Liu, T., Zhang, Q., Pan, Y., ... & Li, W. (2020). HPS1 regulates the maturation of large dense core vesicles and lysozyme secretion in paneth cells. Frontiers in Immunology, 11, 560110.

Jing, R., Zhang, H., Kong, Y., Li, K., Dong, X., Yan, J., ... & Feng, L. (2019). Different functions of biogenesis of lysosomal organelles complex 3 subunit 1 (Hps1) and adaptor-related protein complex 3, beta 1 subunit (Ap3b1) genes on spermatogenesis and male fertility. Reproduction, Fertility and Development, 31(5), 972-982.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-HPS1 Recombinant Antibody (5G12G2) (CAT#: CBMAB-H2924-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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