Mouse Anti-IGF2BP3 Recombinant Antibody (8F11) (CBMAB-I1761-YY)

Name: Mouse Anti-IGF2BP3 Recombinant Antibody (8F11)
SKU: CBMAB-I1761-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8F11

Application

ELISA, IHC, IHC-P, WB, IF

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

.03% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Insulin Like Growth Factor 2 MRNA Binding Protein 3

Introduction

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.

Entrez Gene ID

10643

UniProt ID

O00425

Alternative Names

Insulin Like Growth Factor 2 MRNA Binding Protein 3

Function

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
mRNA transport Source: UniProtKB-KW
Negative regulation of translation Source: BHF-UCL
Nervous system development Source: GO_Central
Regulation of cytokine production Source: BHF-UCL
Regulation of gene expression Source: GO_Central
Regulation of RNA metabolic process Source: GO_Central
Translation Source: ProtInc

Cellular Location

Cytoplasm; Nucleus. Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Yu, Y. Z., Lv, D. J., Wang, C., Song, X. L., Xie, T., Wang, T., ... & Zhao, S. C. (2022). Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p. Molecular cancer, 21, 1-21.

Wan, W., Ao, X., Chen, Q., Yu, Y., Ao, L., Xing, W., ... & Xu, X. (2022). METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer. Molecular cancer, 21(1), 60.

Wang, C., Kong, F., Ma, J., Miao, J., Su, P., Yang, H., ... & Ma, X. (2022). IGF2BP3 enhances the mRNA stability of E2F3 by interacting with LINC00958 to promote endometrial carcinoma progression. Cell death discovery, 8(1), 279.

Wang, X., Tian, L., Li, Y., Wang, J., Yan, B., Yang, L., ... & Sun, Y. (2021). RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. Journal of Experimental & Clinical Cancer Research, 40(1), 1-18.

Zhang, W., Liu, H., Jiang, J., Yang, Y., Wang, W., & Jia, Z. (2021). CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis. Aging (Albany NY), 13(14), 18978.

Mancarella, C., & Scotlandi, K. (2020). IGF2BP3 from physiology to cancer: novel discoveries, unsolved issues, and future perspectives. Frontiers in Cell and Developmental Biology, 7, 363.

Yang, Z., Wang, T., Wu, D., Min, Z., Tan, J., & Yu, B. (2020). RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer. Journal of Experimental & Clinical Cancer Research, 39(1), 1-15.

Hanniford, D., Ulloa-Morales, A., Karz, A., Berzoti-Coelho, M. G., Moubarak, R. S., Sánchez-Sendra, B., ... & Hernando, E. (2020). Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis. Cancer cell, 37(1), 55-70.

Huang, W., Li, Y., Zhang, C., Zha, H., Zhou, X., Fu, B., ... & Wang, G. (2020). IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer. Journal of Cellular and Molecular Medicine, 24(23), 13949-13960.

Xu, W., Sheng, Y., Guo, Y., Huang, Z., Huang, Y., Wen, D., ... & Du, P. (2019). Increased IGF2BP3 expression promotes the aggressive phenotypes of colorectal cancer cells in vitro and vivo. Journal of cellular physiology, 234(10), 18466-18479.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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