Mouse Anti-IRF6 Recombinant Antibody (CBYY-I1904) (CBMAB-I3074-YY)

Name: Mouse Anti-IRF6 Recombinant Antibody (CBYY-I1904)
SKU: CBMAB-I3074-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1904

Application

Immunogen

Full length human recombinant protein of human IRF6(NP_006138)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, PH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.8 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interferon Regulatory Factor 6

Introduction

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

3664

UniProt ID

O14896

Alternative Names

Interferon Regulatory Factor 6

Function

Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity).
Plays a role in regulating mammary epithelial cell proliferation (By similarity).
May regulate WDR65 transcription (By similarity).

Biological Process

Cell developmentIEA:Ensembl
Cranial skeletal system developmentIEA:Ensembl
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Keratinocyte differentiationIEA:Ensembl
Keratinocyte proliferationIEA:Ensembl
Limb developmentIEA:Ensembl
Mammary gland epithelial cell differentiationISS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Roof of mouth developmentIEA:Ensembl

Cellular Location

Cytoplasm; Nucleus. Translocates to nucleus in response to an activating signal.

Involvement in disease

Van der Woude syndrome 1 (VWS1):
An autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate.
Popliteal pterygium syndrome (PPS):
An autosomal dominant disorder characterized by oro-facial, skin and genital anomalies. Expressivity is variable. Clinical features include cleft lip/palate, lower lip cysts, syngnathia, congenital ankyloblepharon filiforme in some cases, bifid scrotum, hypoplastic scrotum, hypoplastic uterus, talipes equinovarus.
Non-syndromic orofacial cleft 6 (OFC6):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.

PTM

Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.

Liang, Y., Liu, R., Zhang, J., Chen, Y., Shan, S., Zhu, Y., ... & Li, H. (2022). Negative regulation of interferon regulatory factor 6 (IRF6) in interferon and NF-κB signalling pathways of common carp (Cyprinus carpio L.). BMC veterinary research, 18(1), 1-12.

Tan, L., Qu, W., Wu, D., Liu, M., Ai, Q., Hu, H., ... & Zhou, H. (2022). The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer. Bioengineered, 13(4), 10504-10517.

Liu, Y., Shao, G., Yang, Z., Lin, X., Liu, X., Qian, B., & Liu, Z. (2021). Interferon regulatory factor 6 correlates with the progression of non-small cell lung cancer and can be regulated by miR-320. Journal of Pharmacy and Pharmacology, 73(5), 682-691.

Li, Z., Yang, W., Qiu, J., Xu, H., Fan, B., Li, K., ... & Li, Y. (2021). Decreased interferon regulatory factor 6 expression due to DNA hypermethylation predicts an unfavorable prognosis in clear cell renal cell carcinoma. Journal of Cancer, 12(22), 6640.

Ren, Y., Dong, J., He, P., Liang, Y., Wu, L., Wang, J., & Chu, B. (2020). miR‐587 promotes cervical cancer by repressing interferon regulatory factor 6. The journal of gene medicine, 22(11), e3257.

Rhea, L., Canady, F. J., Le, M., Reeb, T., Canady, J. W., Kacmarynski, D. S., ... & Dunnwald, M. (2020). Interferon regulatory factor 6 is required for proper wound healing in vivo. Developmental Dynamics, 249(4), 509-522.

Tong, J., Han, C. J., Zhang, J. Z., He, W. Z., Zhao, G. J., Cheng, X. U., ... & Li, H. (2019). Hepatic interferon regulatory factor 6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing peroxisome proliferator‐activated receptor γ in mice. Hepatology, 69(6), 2471-2488.

Metwalli, K. A., Do, M. A., Nguyen, K., Mallick, S., Kin, K., Farokhnia, N., ... & Fakhouri, W. D. (2018). Interferon regulatory factor 6 is necessary for salivary glands and pancreas development. Journal of dental research, 97(2), 226-236.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
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For research use only. Not intended for any clinical use.

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