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Mouse Anti-ITGB3BP Recombinant Antibody (CBYY-I2091) (CBMAB-I3261-YY)

This product is Mouse antibody that recognizes ITGB3BP. The antibody CBYY-I2091 can be used for immunoassay techniques such as: WB
See all ITGB3BP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I2091
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human ITGB3BP (NP_055103)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
integrin subunit beta 3 binding protein
Introduction
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
23421
UniProt ID
Q13352
Alternative Names
Integrin Subunit Beta 3 Binding Protein
Function
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
CENP-A containing chromatin assemblyIEA:InterPro
Regulation of transcription, DNA-templatedIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Isoform 1: Nucleus; Chromosome, centromere; Chromosome, centromere, kinetochore
Isoform 2: Nucleus
Isoform 3: Nucleus; Cytoplasm. Isoform 3 is predominantly nuclear and weakly cytoplasmic.
Isoform 4: Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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