Rabbit Anti-KCTD3 Recombinant Antibody (CBLY1-060) (CBMAB-K0634-LY)

This product is antibody recognizes KCTD3. The antibody CBLY1-060 immunoassay techniques such as: WB.
See all KCTD3 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBLY1-060

Antibody Isotype

IgG

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.287 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Potassium Channel Tetramerization Domain Containing 3

Introduction

This gene encodes a member of the potassium channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-activated cyclic nucleotide-gated channel complex 3 and enhances its cell surface expression and current density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Entrez Gene ID

51133

UniProt ID

Q9Y597

Alternative Names

Potassium Channel Tetramerization Domain Containing 3; Potassium Channel Tetramerisation Domain Containing 3; Renal Carcinoma Antigen NY-REN-45; BTB/POZ Domain-Containing Protein KCTD3; NY-REN-45 Antigen; NY-REN-45;

Function

Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.

Biological Process

Protein homooligomerizationIEA:InterPro

Cellular Location

Cell membrane

References

Shimojima Yamamoto, K., Yoshimura, A., & Yamamoto, T. (2023). Biallelic KCTD3 nonsense variant derived from paternal uniparental isodisomy of chromosome 1 in a patient with developmental epileptic encephalopathy and distinctive features. Human Genome Variation, 10(1), 22.

Faqeih, E. A., Almannai, M., Saleh, M. M., AlWadei, A. H., Samman, M. M., & Alkuraya, F. S. (2018). Phenotypic characterization of KCTD3‐related developmental epileptic encephalopathy. Clinical Genetics, 93(5), 1081-1086.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
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