Mouse Anti-LPP Recombinant Antibody (CBYJL-1944) (CBMAB-L2002-YJ)

Name: Mouse Anti-LPP Recombinant Antibody (CBYJL-1944)
SKU: CBMAB-L2002-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1944

Application

ICC, IF, IHC-P, IP, WB

Immunogen

HIS-tagged recombinant fragment of human LPP.

Specificity

Human, Hamster, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

0.01 M HEPES with 0.15 M NaCl, pH 7.5, 100 μg/ml BSA

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LPP

Introduction

LPP is a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. LPP localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. LPP also shuttles through the nucleus and may function as a transcriptional co-activator. LPP is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	4026
Mouse	210126
Hamster	100753874

UniProt ID

Human	Q93052
Mouse	Q8BFW7

Alternative Names

lipoma-preferred partner; LIM protein; lipoma preferred partner

Function

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

Biological Process

Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm
Cell junction
Cell membrane
Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.

Involvement in disease

A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.
A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.

Panagopoulos, I., Andersen, K., Brunetti, M., Gorunova, L., Lund-Iversen, M., Micci, F., & Heim, S. (2023). Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t (9; 12)(q33; q14) Chromosomal Translocation. in vivo, 37(2), 524-530.

Guo, B., Sallis, R. E., Greenall, A., Petit, M. M., Jansen, E., Young, L., ... & Sharrocks, A. D. (2023). The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Molecular and cellular biology.

Sporkova, A., Nahar, T., Cao, M., Ghosh, S., Sens-Albert, C., Friede, P. A. P., ... & Hecker, M. (2023). Characterisation of Lipoma-Preferred Partner as a Novel Mechanotransducer in Vascular Smooth Muscle Cells. Cells, 12(18), 2315.

Yan, S., Sun, R., Wu, S., Jin, T., Zhang, S., Niu, F., ... & Chen, M. (2019). Single nucleotide polymorphism in the 3′ untranslated region of LPP is a risk factor for lung cancer: a case-control study. BMC cancer, 19, 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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