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Mouse Anti-LRRC4C Recombinant Antibody (CBWJN-1132) (CBMAB-N0946-WJ)

This product is a Mouse antibody that recognizes LRRC4C. The antibody CBWJN-1132 can be used for immunoassay techniques such as: IHC.
See all LRRC4C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1132
Antibody Isotype
IgG1
Application
IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine rich repeat containing 4C
Introduction
LRRC4C (Leucine Rich Repeat Containing 4C) is a Protein Coding gene. Diseases associated with LRRC4C include Extragonadal Seminoma and Chief Cell Adenoma. Among its related pathways are Cell adhesion molecules (CAMs) and Axon guidance. An important paralog of this gene is LRRC4B.
Entrez Gene ID
57689
UniProt ID
Q9HCJ2
Alternative Names
NGL-1, NGL1
Function
May promote neurite outgrowth of developing thalamic neurons.
Biological Process
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axonogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Synaptic membrane adhesionManual Assertion Based On ExperimentIGI:SynGO-UCL
Cellular Location
Cell junction, synapse, postsynaptic cell membrane
Topology
Helical: 528-548

Rajabli, F., Benchek, P., Tosto, G., Kushch, N., Sha, J., Bazemore, K., ... & Lerner, A. (2023). Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium. medRxiv, 2023-07.

Clark, R., Pozarickij, A., Hysi, P. G., Ohno-Matsui, K., Williams, C., Guggenheim, J. A., & UK Biobank Eye and Vision Consortium. (2022). Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia. PLoS Genetics, 18(11), e1010478.

Naj, A. C., Reitz, C., Rajabli, F., Jun, G. R., Benchek, P., Tosto, G., ... & Alzheimer’s Disease Genetics Consortium (ADGC). (2022). Multi‐Ancestry Genome‐wide Association Analysis of Late‐Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies a Novel Cross‐Ancestry Association in LRRC4C. Alzheimer's & Dementia, 18, e065822.

Foss-Skiftesvik, J., Hagen, C. M., Mathiasen, R., Adamsen, D., Bækvad-Hansen, M., Børglum, A. D., ... & Bybjerg-Grauholm, J. (2021). Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25. 2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci. Child's Nervous System, 37, 819-830.

Yang, X., Lei, P., Huang, L., Tang, X., Wei, B., & Wei, H. (2021). Prognostic value of LRRC4C in colon and gastric cancers correlates with tumour microenvironment immunity. International Journal of Biological Sciences, 17(5), 1413.

Choi, Y., Park, H., Kang, S., Jung, H., Kweon, H., Kim, S., ... & Kim, E. (2019). NGL-1/LRRC4C-mutant mice display hyperactivity and anxiolytic-like behavior associated with widespread suppression of neuronal activity. Frontiers in Molecular Neuroscience, 12, 250.

Choi, Y., Park, H., Jung, H., Kweon, H., Kim, S., Lee, S. Y., ... & Kim, E. (2019). NGL-1/LRRC4C deletion moderately suppresses hippocampal excitatory synapse development and function in an input-independent manner. Frontiers in Molecular Neuroscience, 12, 119.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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