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Rat Anti-Ly6d Recombinant Antibody (49-H4) (CBMAB-L2859-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Lymphocyte Antigen 6 Complex Locus D (Ly6d). The antibody can be used for immunoassay techniques, such as FC.
See all Ly6d antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
49-H4
Antibody Isotype
IgG2c, κ
Application
FC

Basic Information

Immunogen
BALB/c mouse plasmacytoma MOPC-104E.
Specificity
Mouse
Antibody Isotype
IgG2c, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lymphocyte antigen 6 complex, locus D
Introduction
Ly6d may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly6d marks the earliest stage of B-cell specification.
Entrez Gene ID
17068
UniProt ID
P35459
Alternative Names
Thb; Ly61; Ly-61; lymphocyte antigen 6D; ly-6D; thymocyte B-cell antigen
Function
May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Lymphocyte differentiationManual Assertion Based On ExperimentIBA:GO_Central
Response to stilbenoidIEA:Ensembl
Cellular Location
Cell membrane

Wang, J., Sheng, N., Li, Y., Fan, Y., Nan, X., & Fu, R. (2023). Ly6D facilitates chemoresistance in laryngeal squamous cell carcinoma through miR-509/β-catenin signaling pathway. American Journal of Cancer Research, 13(5), 2155.

Lee, J., Kim, H., Kang, Y. W., Kim, Y., Park, M. Y., Song, J. H., ... & Park, S. (2023). LY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease. Experimental & Molecular Medicine, 55(7), 1479-1491.

Duan, J., Wang, Y., Chen, Y., Wang, Y., Li, Q., Liu, J., ... & Su, M. (2023). Silencing LY6D Expression Inhibits Colon Cancer in Xenograft Mice and Regulates Colon Cancer Stem Cells’ Proliferation, Stemness, Invasion, and Apoptosis via the MAPK Pathway. Molecules, 28(23), 7776.

Hu, P. X., Sheng, M. Y., Liu, Y. P., & Zhang, C. Q. (2022). FOSL2 deficiency delays nonalcoholic steatohepatitis progression by regulating LY6D-mediated NLRP3 activation. Human Cell, 35(6), 1752-1765.

Nakagawa, K., Nagano, T., Katasho, R., Iwasaki, T., & Kamada, S. (2022). Integrin β1 transduces the signal for LY6D‐induced macropinocytosis and mediates senescence‐inducing stress‐evoked vacuole formation via FAK. FEBS letters, 596(21), 2768-2780.

Nagano, T., Iwasaki, T., Onishi, K., Awai, Y., Terachi, A., Kuwaba, S., ... & Kamada, S. (2021). LY6D-induced macropinocytosis as a survival mechanism of senescent cells. Journal of Biological Chemistry, 296.

Andersson, N., Ohlsson, J., Wahlin, S., Nodin, B., Boman, K., Lundgren, S., & Jirström, K. (2020). Lymphocyte antigen 6 superfamily member D is a marker of urothelial and squamous differentiation: implications for risk stratification of bladder cancer. Biomarker research, 8(1), 1-12.

Upadhyay, G. (2019). Emerging role of lymphocyte antigen-6 family of genes in cancer and immune cells. Frontiers in immunology, 10, 819.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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