Mouse Anti-MEIS3 Recombinant Antibody (CBFYM-0620) (CBMAB-M0754-FY)

This product is mouse antibody that recognizes MEIS3. The antibody CBFYM-0620 can be used for immunoassay techniques such as: ELISA, WB.
See all MEIS3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-0620

Antibody Isotype

IgG1, k

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MEIS3

Introduction

This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells.

Entrez Gene ID

56917

UniProt ID

Q99687

Alternative Names

Meis Homeobox 3; Meis1-Related Protein 2; MRG2; Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3 (Mouse); Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog 3; Homeobox Protein Meis3

Function

Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.

Biological Process

Animal organ morphogenesis Source: GO_Central
Brain development Source: GO_Central
Embryonic pattern specification Source: GO_Central
Eye development Source: GO_Central
Negative regulation of apoptotic signaling pathway Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of protein kinase B signaling Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

References

Ma, J., Li, H., Gao, Q., Zhang, W., Zhu, C., Chen, J., ... & Li, Z. (2023). High MEIS3 Expression Indicates a Poor Prognosis for Patients with Stage II/III Colorectal Cancer. Frontiers in Bioscience-Landmark, 28(12), 338.

Durant-Vesga, J., Suzuki, N., Ochi, H., Le Bouffant, R., Eschstruth, A., Ogino, H., ... & Riou, J. F. (2023). Retinoic acid control of pax8 during renal specification of Xenopus pronephros involves hox and meis3. Developmental Biology, 493, 17-28.

Krasnytska, D. A., Khita, O. O., Tsymbal, D. O., Luzina, O. Y., Cherednychenko, A. A., Kozynkevich, H. E., ... & Minchenko, D. O. (2022). The impact of glutamine deprivation on the expression of MEIS3, SPAG4, LHX1, LHX2, and LHX6 genes in ERN1 knockdown U87 glioma cells. Endocrine Regulations, 56(1), 38-47.

Li, H., Jian, M., & Ling, Y. (2022). High MEIS3 level in colorectal cancer of stage II/III indicates poor prognosis.

Zhang, Y., Pan, Q., & Shao, Z. (2021). Tumor-suppressive role of microRNA-202-3p in hepatocellular carcinoma through the KDM3A/HOXA1/MEIS3 pathway. Frontiers in Cell and Developmental Biology, 8, 556004.

Cai, P., Xie, Y., Dong, M., & Zhu, Q. (2020). Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt. BioMed Research International, 2020.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-MEIS3 (AA 1-261 ) Recombinant Antibody (CBFYM-2046)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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