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Rabbit Anti-MESD Recombinant Antibody (CBFYM-2088) (CBMAB-M2269-FY)

This product is rabbit antibody that recognizes MESD. The antibody CBFYM-2088 can be used for immunoassay techniques such as: WB, IHC-P, IP.
See all MESD antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBFYM-2088
Antibody Isotype
IgG
Application
WB, IHC-P, IP

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 0.15 M NaCl, 0.01% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mesoderm Development LRP Chaperone
Introduction
MESD is a Protein Coding gene. Diseases associated with MESD include Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 2. Among its related pathways are Wnt/Hedgehog/Notch.
Entrez Gene ID
Human23184
Mouse67943
Rat308796
Monkey712993
UniProt ID
HumanQ14696
MouseQ9ERE7
RatQ5U2R7
MonkeyG7MYN0
Alternative Names
Mesoderm Development LRP Chaperone; Mesoderm Development Candidate 2; Mesoderm Development LRP Chaperone MESD; Renal Carcinoma Antigen NY-REN-61; Mesoderm Development Protein; LDLR Chaperone MESD
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed:15014448).

Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane (PubMed:17488095).

Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity).

May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).
Biological Process
Mesoderm development Source: UniProtKB
Ossification Source: UniProtKB
Phagocytosis Source: UniProtKB
Positive regulation of skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
Protein folding Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum
Note: Released from apoptotic cells and shed photoreceptor outer segments.
Involvement in disease
Osteogenesis imperfecta 20 (OI20):
An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI20 is a progressive deforming form characterized by osteopenia, skeletal deformity, healed fractures, and newly-acquired fractures. Death due to respiratory failure can occur in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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