Rabbit Anti-MPZL1 Recombinant Antibody (D17B10) (CBMAB-CP2154-LY)

Name: Rabbit Anti-MPZL1 Recombinant Antibody (D17B10)
SKU: CBMAB-CP2154-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D17B10

Application

WB, IP, IF (ICC)

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu209 of human PZR protein.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Myelin Protein Zero Like 1

Entrez Gene ID

9019

UniProt ID

O95297

Function

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Biological Process

Cell-cell signaling Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Cellular Location

Membrane

Involvement in disease

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).
N-glycosylated. N-glycosylation is required for concanavalin A binding (PubMed:30392906).

Topology

Extracellular: 36-162
Helical: 163-183
Cytoplasmic: 184-269

Song, H., Ni, B., Peng, X., Xu, W., Yang, S., Yang, R., ... & Liu, Y. (2023). MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma. Genes & Diseases, 101085.

Wang, A., Fan, F., Zang, C., Li, C., Hong, H., Wang, Z., ... & Zhao, C. (2023). MPZL1 promotes LUAD progression by enhancing tumor proliferation, invasion, migration and suppressing immune function via TGF-β1. Human Gene Therapy, (ja).

Ge, Q., Zhou, C., Zang, C., Li, C., Hong, H., Wang, K., ... & Wang, A. (2023). MPZL1 suppresses the cancer stem-like properties of lung cancer through β-catenin/TCF4 signaling. Functional & Integrative Genomics, 23(4), 304.

Sun, D., Gou, H., Wang, D., Li, C., Li, Y., Su, H., ... & Yu, J. (2022). LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly binding to oncogenic MPZL1 and is associated with patient outcome. International Journal of Biological Sciences, 18(8), 3156.

Feng, J., Ouyang, H., Wang, J., Pan, D., Sheng, L., Xu, C., ... & Jia, D. (2022). MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer. Carcinogenesis, 43(10), 919-929.

Ye, Y., Gu, J., Liu, P., Wang, H., Jiang, L., Lei, T., ... & Wang, Z. (2020). Long non-coding RNA SPRY4-IT1 reverses cisplatin resistance by downregulating MPZL-1 via suppressing EMT in NSCLC. OncoTargets and therapy, 2783-2793.

Liu, X., Huang, J., Liu, L., & Liu, R. (2019). MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC‑SD cells. Molecular Medicine Reports, 20(3), 2725-2733.

Chen, D., Cao, L., & Wang, X. (2019). MPZL1 promotes tumor cell proliferation and migration via activation of Src kinase in ovarian cancer. Oncology reports, 42(2), 679-687.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-MPZL1 Recombinant Antibody (D17B10) (CAT#: CBMAB-P0509-YC)

Related Products

Rabbit Anti-MPZL1 Recombinant Antibody (D17B10) (CAT#: CBMAB-P0509-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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