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Mouse Anti-MS4A6A Recombinant Antibody (CBFYM-0731) (CBMAB-M0873-FY)

This product is mouse antibody that recognizes MS4A6A. The antibody CBFYM-0731 can be used for immunoassay techniques such as: ELISA, WB.
See all MS4A6A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0731
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
membrane-spanning 4-domains, subfamily A, member 6A
Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms.
Entrez Gene ID
64231
UniProt ID
Q9H2W1
Alternative Names
Membrane Spanning 4-Domains A6A; Membrane-Spanning 4-Domains, Subfamily A, Member 6A; Four-Span Transmembrane Protein 3; CD20 Antigen-Like 3; 4SPAN3; CD20L3; MS4A6; Membrane-Spanning 4-Domains Subfamily A Member 6A; Four-Span Transmembrane Protein 3.1
Function
May be involved in signal transduction as a component of a multimeric receptor complex.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Cytoplasmic: 1-46
Helical: 47-67
Extracellular: 68-84
Helical: 85-105
Cytoplasmic: 106-116
Helical: 117-137
Extracellular: 138-185
Helical: 186-206
Cytoplasmic: 207-248

Bitting, K., Hedgespeth, B., Ehrhardt‐Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., ... & Cruse, G. (2023). Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling. Allergy, 78(5), 1204-1217.

Zhang, C., Liu, H., Tan, Y., Xu, Y., Li, Y., Tong, S., ... & Zhong, C. (2022). MS4A6A is a new prognostic biomarker produced by macrophages in glioma patients. Frontiers in immunology, 13, 865020.

Bitting, K. J., Hedgespeth, B., Ehrhardt-Humbert, L. C., Arthur, G., Bradding, P., Tilley, S. L., & Cruse, G. (2022). Identification of redundancy between human FcɛRIβ and MS4A6A proteins points toward additional mechanisms for FcɛRI trafficking and signaling. The Journal of Immunology, 208(1_Supplement), 49-17.

Abd Elrahman, H. G., Ramadan, A., Saleh, E. M., Saleh, A. A., Sabry, N. A., & Mohamed, M. R. (2020). Association study of polymorphisms in ABCA7, clusterin, and MS4A6A genes with Alzheimer’s disease in the Egyptian population. Turkish Journal of Biochemistry, 45(6), 757-765.

Mehdizadeh, E., Khalaj-Kondori, M., Shaghaghi-Tarakdari, Z., Sadigh-Eteghad, S., Talebi, M., & Andalib, S. (2019). Association of MS4A6A, CD33, and TREM2 gene polymorphisms with the late-onset Alzheimer’s disease. BioImpacts: BI, 9(4), 219.

Hou, X. H., Bi, Y. L., Tan, M. S., Xu, W., Li, J. Q., Shen, X. N., ... & Alzheimer's Disease Neuroimaging Initiative. (2019). Genome-wide association study identifies Alzheimer's risk variant in MS4A6A influencing cerebrospinal fluid sTREM2 levels. Neurobiology of aging, 84, 241-e13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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