Mouse Anti-MYOM2 Recombinant Antibody (CBFYM-3015) (CBMAB-M3210-FY)

This product is mouse antibody that recognizes MYOM2. The antibody CBFYM-3015 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MYOM2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-3015

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MYOMESIN 2

Introduction

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical.

Entrez Gene ID

9172

UniProt ID

P54296

Alternative Names

Myomesin 2; 165 KDa Connectin-Associated Protein; 165 KDa Titin-Associated Protein; Myomesin (M-Protein) 2, 165kDa; Myomesin Family Member 2; M-Protein

Function

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

Biological Process

Muscle contraction Source: GO_Central
Sarcomere organization Source: FlyBase

Cellular Location

M line

References

Ji, M., Su, L., Liu, L., Zhuang, M., Xiao, J., Guan, Y., ... & Pu, H. (2023). CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms. Scientific Reports, 13(1), 5827.

Wang, J., Wang, C., Xie, H., Feng, X., Wei, L., Wang, B., ... & Gong, L. (2022). Case Report: Tetralogy of Fallot in a Chinese Family Caused by a Novel Missense Variant of MYOM2. Frontiers in Cardiovascular Medicine, 9, 863650.

Auxerre-Plantié, E., Nielsen, T., Grunert, M., Olejniczak, O., Perrot, A., Özcelik, C., ... & Sperling, S. R. (2020). Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart. Disease models & mechanisms, 13(12), dmm045377.

Liu, J., Zhu, Q., Han, J., Zhang, H., Li, Y., Ma, Y., ... & Wang, J. (2019). IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis. Molecular Medicine, 25, 1-7.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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