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Mouse Anti-NEK1 Recombinant Antibody (E-10) (CBMAB-N1915-WJ)

This product is a Mouse antibody that recognizes NEK1. The antibody E-10 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NEK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
E-10
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NIMA Related Kinase 1
Introduction
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Entrez Gene ID
Human4750
Mouse18004
Rat290705
UniProt ID
HumanQ96PY6
MouseP51954
RatD3ZB99
Alternative Names
NIMA Related Kinase 1; NIMA (Never In Mitosis Gene A)-Related Kinase 1; Never In Mitosis A-Related Kinase 1; Renal Carcinoma Antigen NY-REN-55; NimA-Related Protein Kinase 1; EC 2.7.11.1; Serine/Threonine-Protein Kinase Nek1; Protein-Serine/Threonine Kinase;
Function
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784).

Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784).

In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784).

May be implicated in the control of meiosis (By similarity).

Involved in cilium assembly (PubMed:21211617).
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cilium assembly Source: UniProtKB
Protein phosphorylation Source: CACAO
Cellular Location
Nucleus
Cytoskeleton
centrosome
Cytoplasm
Note: Associated with the pericentriolar material (PubMed:21211617). Localizes to centrosome during interphase and mitosis (By similarity). Translocated from cytoplasm to discrete nuclear foci at sites of DNA damage (PubMed:15604234).
Involvement in disease
Short-rib thoracic dysplasia 6 with or without polydactyly (SRTD6):
A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome.
Amyotrophic lateral sclerosis 24 (ALS24):
A form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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