Rabbit Anti-NT5C3A Recombinant Antibody (CBWJN-1565) (CBMAB-N3678-WJ)

Name: Rabbit Anti-NT5C3A Recombinant Antibody (CBWJN-1565)
SKU: CBMAB-N3678-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBWJN-1565

Application

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

5'-Nucleotidase, Cytosolic IIIA

Introduction

This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]

Entrez Gene ID

51251

UniProt ID

Q9H0P0

Alternative Names

5'-Nucleotidase, Cytosolic IIIA; 5-Nucleotidase, Cytosolic IIIA; 7-Methylguanosine Phosphate-Specific 5-Nucleotidase; Uridine 5-Monophosphate Hydrolase 1; 5-Nucleotidase, Cytosolic III; Pyrimidine 5-Nucleotidase 1; Cytosolic 5-Nucleotidase 3; CN-III; Lupin; NT5C3; P5N-1; UMPH1; PN-I;

Function

Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m7GMP) (PubMed:24603684).
CMP seems to be the preferred substrate (PubMed:15968458).

Biological Process

Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Nucleotide metabolic processIEA:UniProtKB-KW
Pyrimidine nucleoside metabolic process1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm
Isoform 2
Endoplasmic reticulum

Involvement in disease

P5N deficiency (P5ND):
Autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associated with learning difficulties.

Bogusławska, D. M., Skulski, M., Bartoszewski, R., Machnicka, B., Heger, E., Kuliczkowski, K., & Sikorski, A. F. (2022). A rare mutation (p. F149del) of the NT5C3A gene is associated with pyrimidine 5′-nucleotidase deficiency. Cellular & Molecular Biology Letters, 27(1), 104.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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