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Rabbit Anti-NT5C3A Recombinant Antibody (CBWJN-1565) (CBMAB-N3678-WJ)

This product is a Rabbit antibody that recognizes NT5C3A. The antibody CBWJN-1565 can be used for immunoassay techniques such as: WB.
See all NT5C3A antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJN-1565
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5'-Nucleotidase, Cytosolic IIIA
Introduction
This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]
Entrez Gene ID
51251
UniProt ID
Q9H0P0
Alternative Names
5'-Nucleotidase, Cytosolic IIIA; 5-Nucleotidase, Cytosolic IIIA; 7-Methylguanosine Phosphate-Specific 5-Nucleotidase; Uridine 5-Monophosphate Hydrolase 1; 5-Nucleotidase, Cytosolic III; Pyrimidine 5-Nucleotidase 1; Cytosolic 5-Nucleotidase 3; CN-III; Lupin; NT5C3; P5N-1; UMPH1; PN-I;
Function
Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m7GMP) (PubMed:24603684).
CMP seems to be the preferred substrate (PubMed:15968458).
Biological Process
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Nucleotide metabolic processIEA:UniProtKB-KW
Pyrimidine nucleoside metabolic process1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Isoform 2
Endoplasmic reticulum
Involvement in disease
P5N deficiency (P5ND):
Autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associated with learning difficulties.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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