Sign in or Register   Sign in or Register
  |  

Rabbit Anti-NUCB2 Recombinant Antibody (NET1) (CBMAB-N3853-WJ)

This product is a Rabbit antibody that recognizes NUCB2. The antibody NET1 can be used for immunoassay techniques such as: WB, ICC, IHC, IP.
See all NUCB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
NET1
Application
WB, ICC, IHC, IP

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nucleobindin 2
Introduction
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Entrez Gene ID
Human4925
Mouse53322
Rat59295
UniProt ID
HumanP80303
MouseP81117
RatQ9JI85
Alternative Names
Nucleobindin 2; Gastric Cancer Antigen Zg4; DNA-Binding Protein NEFA; Prepronesfatin; NEFA; Epididymis Secretory Protein Li 109;
Function
Calcium-binding protein which may have a role in calcium homeostasis (By similarity).
Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity).
Nesfatin-1
Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.
Biological Process
Negative regulation of appetiteIEA:InterPro
Small GTPase mediated signal transductionISS:UniProtKB
Cellular Location
Golgi apparatus
Membrane
Cytoplasm
Secreted
Endoplasmic reticulum
Nucleus envelope
Golgi retention is mediated by its N-terminal region.
Nesfatin-1
Secreted

Zheng, J., Han, J., Wang, Y., & Tian, Z. (2023). Role of brain NUCB2/nesfatin-1 in stress and stress-related gastrointestinal disorders. Peptides, 171043.

Ning, S., Liu, C., Wang, K., Cai, Y., Ning, Z., Li, M., & Zeng, L. (2023). NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway. Journal of translational medicine, 21(1), 362.

Caroleo, M., Carbone, E. A., Arcidiacono, B., Greco, M., Primerano, A., Mirabelli, M., ... & Brunetti, A. (2023). Does NUCB2/nesfatin-1 influence eating behaviors in obese patients with binge eating disorder? Toward a neurobiological pathway. Nutrients, 15(2), 348.

Kmiecik, A., Ratajczak-Wielgomas, K., Grzegrzółka, J., Romanowicz, H., Smolarz, B., & Dziegiel, P. (2022). Expression of NUCB2/NESF-1 in breast Cancer cells. International Journal of Molecular Sciences, 23(16), 9177.

Zhou, Q., Liu, Y., Feng, R., & Zhang, W. (2022). NUCB2: roles in physiology and pathology. Journal of physiology and biochemistry, 78(3), 603-617.

Weibert, E., Hofmann, T., Elbelt, U., Rose, M., & Stengel, A. (2022). NUCB2/nesfatin-1 is associated with severity of eating disorder symptoms in female patients with obesity. Psychoneuroendocrinology, 143, 105842.

Schalla, M. A., Goebel-Stengel, M., Friedrich, T., Kühne, S. G., Kobelt, P., Rose, M., & Stengel, A. (2020). Restraint stress affects circulating NUCB2/nesfatin-1 and phoenixin levels in male rats. Psychoneuroendocrinology, 122, 104906.

Schalla, M. A., Unniappan, S., Lambrecht, N. W., Mori, M., Taché, Y., & Stengel, A. (2020). NUCB2/nesfatin-1–Inhibitory effects on food intake, body weight and metabolism. Peptides, 128, 170308.

Yang, Y., Zhang, B., Nakata, M., Nakae, J., Mori, M., & Yada, T. (2019). Islet β-cell-produced NUCB2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing UCP-2 in β-cells. The journal of physiological sciences, 69, 733-739.

Zhao, J., Yun, X., Ruan, X., Chi, J., Yu, Y., Li, Y., ... & Gao, M. (2019). High expression of NUCB2 promotes papillary thyroid cancer cells proliferation and invasion. OncoTargets and therapy, 1309-1318.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-NUCB2 Recombinant Antibody (NET1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare