Mouse Anti-ONECUT3 (AA 350-455) Recombinant Antibody (CBXO-0194) (CBMAB-O0454-CQ)

This product is a mouse antibody that recognizes ONECUT3 (AA 350-455). The antibody CBXO-0194 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all ONECUT3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXO-0194

Antibody Isotype

IgG1

Application

WB, ELISA, IHC

Basic Information

Immunogen

Purified recombinant fragment of human ONECUT3 (AA: 350-455) expressed in E. Coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 350-455

Target

Full Name

One Cut Homeobox 3

Introduction

ONECUT3 (One Cut Homeobox 3) is a Protein Coding gene. Diseases associated with ONECUT3 include Dracunculiasis. Among its related pathways are Regulation of beta-cell development and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is ONECUT2.

Entrez Gene ID

390874

UniProt ID

O60422

Alternative Names

One Cut Homeobox 3; Transcription Factor ONECUT-3; OC-3; One Cut Domain, Family Member 3; One Cut Domain Family Member 3; OC3

Function

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

Biological Process

Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

References

Chen, P. C., Ning, Y., Li, H., Su, J. G., Shen, J. B., Feng, Q. C., ... & Guo, R. S. (2023). Targeting ONECUT3 blocks glycolytic metabolism and potentiates anti-PD-1 therapy in pancreatic cancer. Cellular Oncology, 1-16.

Shi, H., Tsang, Y., Yang, Y., & Chin, H. L. (2023). Identification of ONECUT3 as a stemness-related transcription factor regulating NK cell-mediated immune evasion in pancreatic cancer. Scientific Reports, 13(1), 18133.

Luo, Y., Feng, X., Lang, W., Mei, C., Xu, R., Huang, G., & Tong, H. (2022). The Transcriptional Factor ONECUT3 Is a Driver and Therapeutic Target for Complex Karyotype MDS. Blood, 140(Supplement 1), 4018-4019.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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