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Mouse Anti-PLOD1 Recombinant Antibody (CBYJL-2309) (CBMAB-L2601-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 1 (PLOD1). The antibody can be used for immunoassay techniques, such as ELISA.
See all PLOD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2309
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Native purified human Luteinizing Hormone from human pituitary glands.Immunogen sequence:.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Introduction
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been observed for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
LH; LH1; LLH; EDS6; PLOD; EDSKCL1
Function
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity).
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030).
These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable).
Biological Process
Epidermis developmentManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-lysine hydroxylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to hypoxiaManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Rough endoplasmic reticulum membrane
Involvement in disease
Ehlers-Danlos syndrome, kyphoscoliotic type, 1 (EDSKSCL1):
A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSKSCL1 is an autosomal recessive form characterized by severe muscle hypotonia at birth, generalized joint laxity, scoliosis at birth, and scleral fragility and rupture of the ocular globe.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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