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Rabbit Anti-POU4F1 Recombinant Antibody (EP1972Y) (CBMAB-1677-CN)

This product is a rabbit antibody that recognizes POU4F1 of human. The antibody EP1972Y can be used for immunoassay techniques such as: FC, IF, IP, WB.
See all POU4F1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EP1972Y
Antibody Isotype
IgG
Application
FC, IF, IP, WB

Basic Information

Immunogen
Synthetic peptide from the C terminal region of Human BRN3A
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 0.05% BSA, 50% Glycerol
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POU class 4 homeobox 1
Introduction
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor.
Entrez Gene ID
Human5457
Mouse18996
Rat114503
UniProt ID
HumanQ01851
MouseP17208
RatP20266
Alternative Names
BRN3A; RDC-1; Oct-T1; brn-3A
Function
Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.
Isoform 2
Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells.
Biological Process
AxonogenesisManual Assertion Based On ExperimentTAS:BHF-UCL
Cell migration in hindbrainIEA:Ensembl
Cellular response to cytokine stimulusISS:UniProtKB
Cellular response to estradiol stimulusISS:UniProtKB
Central nervous system neuron differentiationIEA:Ensembl
Habenula developmentIEA:Ensembl
Heart developmentISS:ARUK-UCL
InnervationManual Assertion Based On ExperimentTAS:BHF-UCL
Intrinsic apoptotic signaling pathway by p53 class mediatorISS:UniProtKB
Mesoderm developmentIEA:Ensembl
Negative regulation of apoptotic processBy SimilarityISS:ARUK-UCL
Negative regulation of gene expressionISS:ARUK-UCL
Negative regulation of neuron apoptotic processISS:UniProtKB
Negative regulation of programmed cell deathISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Neuron apoptotic processIEA:Ensembl
Neuron fate specificationISS:BHF-UCL
Neuron migrationIEA:Ensembl
Neuron projection developmentISS:UniProtKB
Peripheral nervous system neuron developmentISS:BHF-UCL
Positive regulation of gene expressionISS:UniProtKB
Positive regulation of neuron apoptotic processIEA:Ensembl
Positive regulation of osteoclast differentiationISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIBy SimilarityIDA:ParkinsonsUK-UCL
Positive regulation of transcription regulatory region DNA bindingISS:UniProtKB
Proprioception involved in equilibrioceptionIEA:Ensembl
Regulation of cell cycleISS:UniProtKB
Regulation of DNA-binding transcription factor activityISS:UniProtKB
Regulation of neurogenesisIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Sensory system developmentISS:BHF-UCL
Suckling behaviorIEA:Ensembl
Synapse assemblyManual Assertion Based On ExperimentTAS:ProtInc
Trigeminal nerve developmentISS:BHF-UCL
Ventricular compact myocardium morphogenesisIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
Ataxia, intention tremor, and hypotonia syndrome, childhood-onset (ATITHS):
An autosomal dominant neurodevelopmental disorder characterized by global developmental delay, mildly impaired intellectual development with speech delay or learning disabilities, delayed walking due to ataxia, intention tremor, and hypotonia apparent from early childhood. Brain imaging shows cerebellar atrophy in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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