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Mouse Anti-PPP2R5C Recombinant Antibody (TQ11-1G6) (CBMAB-P2645-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 2 Regulatory Subunit B'Gamma. The antibody can be used for immunoassay techniques, such as IHC, IHC-P, IP, WB.
See all PPP2R5C antibodies
Published Data
Fig.1 Western blot results showing the expression of endogenous B56ε and B56γ in tissue culture cell lines.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
TQ11-1G6
Antibody Isotype
IgG1, κ
Application
IHC, IHC-P, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
50 mM sodium borate
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 2, regulatory subunit B', gamma isoform
Introduction
PPP2R5C belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits.
Entrez Gene ID
5527
UniProt ID
Q13362
Alternative Names
B56G; B56gamma; PR61G
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIDA:UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMP:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:MGI
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Nucleus
Chromosome, centromere
PTM
Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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