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Mouse Anti-PSMC6 Recombinant Antibody (2C4) (CBMAB-P3209-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteasome 26S Subunit, ATPase 6. The antibody can be used for immunoassay techniques, such as ELISA, IF, RNAi, WB.
See all PSMC6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C4
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, RNAi, WB

Basic Information

Immunogen
PSMC6 (AAH05390, 290-389 aa) partial recombinant protein with GST tag. Immunogen sequence: LRPGRLDRKI HIDLPNEQAR LDILKIHAGP ITKHGEIDYE AIVKLSDGFN GADLRNVCTE AGMFAIRADH DFVVQEDFMK AVRKVADSKK LESKLDYKPV
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 290-389

Target

Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 6
Introduction
PSMC6 (Proteasome 26S Subunit, ATPase 6) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include hydrolase activity and protein binding, bridging.
Entrez Gene ID
5706
UniProt ID
P62333
Alternative Names
CADP44; HEL-S-73; P44; SUG2; p42
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Biological Process
Positive regulation of inclusion body assemblyIEA:Ensembl
Positive regulation of proteasomal protein catabolic process1 PublicationIC:UniProtKB
Positive regulation of RNA polymerase II transcription preinitiation complex assemblyManual Assertion Based On ExperimentIBA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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