Sign in or Register   Sign in or Register
  |  

Mouse Anti-RAB39B Recombinant Antibody (1E11) (CBMAB-R0840-CN)

This product is a Mouse antibody that recognizes RAB39B. The antibody 1E11 can be used for immunoassay techniques such as: ELISA, WB.
See all RAB39B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E11
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa. 1-214 from human RAB39B (H09714) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB39B, member RAS oncogene family
Introduction
This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking. Mutations in this gene are associated with X-linked cognitive disability. [provided by RefSeq, Aug 2013]
Entrez Gene ID
116442
UniProt ID
Q96DA2
Alternative Names
RAB39B, Member RAS Oncogene Family; Waisman Syndrome; Waisman Syndrome (Basal Ganglion Disorder With Mental Retardation); Mental Retardation, X-Linked 72; Ras-Related Protein Rab-39B; MRX72; BGMR; WSMN; WSN;
Function
Small GTPases Rab involved in autophagy (PubMed:27103069).
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069).
May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity).
Biological Process
Biological Process autophagyIEA:UniProtKB-KW
Biological Process protein transportIEA:UniProtKB-KW
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process synapse organizationISS:UniProtKB
Biological Process vesicle-mediated transportISS:UniProtKB
Cellular Location
Cell membrane
Cytoplasmic vesicle membrane
Golgi apparatus
Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network.
Involvement in disease
Intellectual developmental disorder, X-linked 72 (XLID72):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked forms, while syndromic forms present with associated physical, neurological and/or psychiatric manifestations. XLID72 patients can manifest autism spectrum disorder, seizures and macrocephaly as additional features.
Waisman syndrome (WSMN):
A neurologic disorder characterized by delayed psychomotor development, intellectual disability, and early-onset Parkinson disease.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RAB39B Recombinant Antibody (1E11)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare