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Mouse Anti-RERE Recombinant Antibody (REREF1H8) (CBMAB-R2199-CN)

This product is a Mouse antibody that recognizes RERE. The antibody REREF1H8 can be used for immunoassay techniques such as: WB, Dot, IF.
See all RERE antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human
Clone
REREF1H8
Antibody Isotype
IgG2b
Application
WB, Dot, IF

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.1 mg/mL

Target

Full Name
arginine-glutamic acid dipeptide (RE) repeats
Introduction
This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human473
Rat116665
UniProt ID
HumanQ9P2R6
RatQ62901
Alternative Names
Arginine-Glutamic Acid Dipeptide Repeats; Arginine-Glutamic Acid Dipeptide (RE) Repeats; ATN1L; ARG; ARP; Arginine-Glutamic Acid Dipeptide Repeats Protein; Atrophin-1 Related Protein; Atrophin-1-Related Protein;
Function
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Biological Process
Biological Process branching morphogenesis of a nerveIEA:Ensembl
Biological Process cerebellar granule cell precursor proliferationIEA:Ensembl
Biological Process cerebellar Purkinje cell layer maturationIEA:Ensembl
Biological Process chromatin remodelingIEA:Ensembl
Biological Process dendrite morphogenesisIEA:Ensembl
Biological Process radial glia guided migration of Purkinje cellIEA:Ensembl
Cellular Location
Nucleus
Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
Involvement in disease
Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH):
An autosomal dominant syndrome characterized by developmental delay, intellectual disability, brain anomalies, and neurological abnormalities including seizures, hypotonia, and behavioral problems such as autism spectrum disorders. Brain anomalies include abnormalities and/or thinning of the corpus callosum, diminished white matter volume, abnormal cerebellar vermis, and ventriculomegaly. Congenital defects of the eye, heart and genitourinary system are present in half of the patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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