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Mouse Anti-RFXAP Recombinant Antibody (1B5) (CBMAB-R2400-CN)

This product is a Mouse antibody that recognizes RFXAP. The antibody 1B5 can be used for immunoassay techniques such as: ELISA, WB.
See all RFXAP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B5
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
RFXAP (NP_000529, aa. 179-244) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
No preservatives
Concentration
1 mg/mL

Target

Full Name
regulatory factor X-associated protein
Introduction
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5994
UniProt ID
O00287
Alternative Names
Regulatory Factor X Associated Protein; Regulatory Factor X-Associated Protein; RFX DNA-Binding Complex 36 KDa Subunit; RFX-Associated Protein;
Function
Part of the RFX complex that binds to the X-box of MHC II promoters.
Biological Process
Biological Process positive regulation of MHC class II biosynthetic process1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Bare lymphocyte syndrome 2 (BLS2):
A severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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