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Mouse Anti-RNF145 Recombinant Antibody (CBCNR-582) (CBMAB-R2946-CN)

This product is a Mouse antibody that recognizes RNF145. The antibody CBCNR-582 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF145 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-582
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
FLJ31951 (NP_653327, aa. 592-691) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
Ring Finger Protein 145
Introduction
RNF145 (Ring Finger Protein 145) is a Protein Coding gene. An important paralog of this gene is RNF139.
Entrez Gene ID
153830
UniProt ID
Q96MT1
Alternative Names
Ring Finger Protein 145;
Function
E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately down-regulating cholesterol biosynthesis.
Cellular Location
Endoplasmic reticulum membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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