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Mouse Anti-ROS1 Recombinant Antibody (V2-84138) (CBMAB-R3238-CN)

This product is a Mouse antibody that recognizes ROS1. The antibody 4B9 can be used for immunoassay techniques such as: WB.
See all ROS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-84138
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to aa. 2126-2347 of human ROS1 (NP_002935) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
ROS Proto-Oncogene 1, Receptor Tyrosine Kinase
Introduction
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6098
UniProt ID
P08922
Alternative Names
ROS Proto-Oncogene 1, Receptor Tyrosine Kinase; V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1; C-Ros Oncogene 1, Receptor Tyrosine Kinase; Proto-Oncogene C-Ros-1; MCF3; ROS; V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian); ROS Proto-Oncogene 1, Receptor Tyrosine Kinase;
Function
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Biological Process
Biological Process cell differentiationISS:UniProtKB
Biological Process columnar/cuboidal epithelial cell developmentISS:UniProtKB
Biological Process positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spermatogenesisISS:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells.
Topology
Extracellular: 28-1859
Helical: 1860-1882
Cytoplasmic: 1883-2347
PTM
Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity).
Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity).
Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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