Mouse Anti-SCN9A Recombinant Antibody (A1420) (CBMAB-AP12490LY)

Name: Mouse Anti-SCN9A Recombinant Antibody (A1420)
SKU: CBMAB-AP12490LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

A1420

Application

ICC/IF, AM, IP, WB

Immunogen

Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7

Specificity

Hamster, Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Sodium Voltage-Gated Channel Alpha Subunit 9

Introduction

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]

Entrez Gene ID

Human	6335
Mouse	20274
Rat	78956
Hamster	101843265

UniProt ID

Human	Q15858
Mouse	Q62205
Rat	O08562
Hamster	A0A8C2MDS3

Alternative Names

Sodium Voltage-Gated Channel Alpha Subunit 9; Sodium Channel, Voltage-Gated, Type IX, Alpha Polypeptide; Sodium Channel, Voltage-Gated, Type IX, Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.7; Sodium Channel Protein Type IX Subunit Alpha; Neuroendocrine Sodium Channel; Peripheral Sodium Channel 1; HNE-Na; NENA; PN1; Sodium Channel, Voltage Gated, Type IX Alpha Subunit;

Function

SMC-314S

Biological Process

Biological Process behavioral response to formalin induced painIEA:Ensembl
Biological Process inflammatory responseIEA:Ensembl
Biological Process membrane depolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of action potentialIEA:Ensembl
Biological Process neuronal action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process post-embryonic developmentIEA:Ensembl
Biological Process regulation of ion transmembrane transportIEA:UniProtKB-KW
Biological Process response to coldIEA:Ensembl
Biological Process response to heatIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process sensory perception of painManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion transportManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Cell projection, neuron projection
In neurite terminals.

Involvement in disease

Primary erythermalgia (PERYTHM):
Autosomal dominant disease characterized by recurrent episodes of severe pain associated with redness and warmth in the feet or hands.
Indifference to pain, congenital, autosomal recessive (CIP):
A disorder characterized by congenital inability to perceive any form of pain, in any part of the body. All other sensory modalities are preserved and the peripheral and central nervous systems are apparently intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception, tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory neuropathy, either axonal or demyelinating.
Paroxysmal extreme pain disorder (PEPD):
Autosomal dominant paroxysmal disorder of pain and autonomic dysfunction. The distinctive features are paroxysmal episodes of burning pain in the rectal, ocular, and mandibular areas accompanied by autonomic manifestations such as skin flushing.

PTM

Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.
Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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