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Rabbit Anti-STAR Recombinant Antibody (CBXS-5330) (CBMAB-S2544-CQ)

This product is a rabbit antibody that recognizes STAR. The antibody CBXS-5330 can be used for immunoassay techniques such as: WB, IP, IF.
See all STAR antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXS-5330
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
steroidogenic acute regulatory protein
Introduction
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
Entrez Gene ID
Human6770
Mouse20845
Rat25557
UniProt ID
HumanP49675
MouseP51557
RatP97826
Alternative Names
STARD1
Function
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Biological Process
Biological Process cellular lipid metabolic processIEA:Ensembl
Biological Process cholesterol metabolic processIEA:UniProtKB-UniPathway
Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process intracellular cholesterol transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of bile acid biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of steroid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process steroid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion
Involvement in disease
Adrenal hyperplasia 1 (AH1):
The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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