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Mouse Anti-UBE2L3 Recombinant Antibody (CBFYU-127) (CBMAB-U0127-FY)

This product is mouse antibody that recognizes UBE2L3. The antibody CBFYU-127 can be used for immunoassay techniques such as: WB, IF.
See all UBE2L3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Frog, Mouse, Rat
Clone
CBFYU-127
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Human UBE2L3
Specificity
Human, Dog, Frog, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 15-133

Target

Full Name
Ubiquitin Conjugating Enzyme E2 L3
Introduction
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Down-regulated during the S-phase it is involved in progression through the cell cycle.
Entrez Gene ID
Human7332
Mouse22195
Rat363836
Frog548817
Dog477572
UniProt ID
HumanP68036
MouseP68037
RatD3Z8W5
FrogQ5BJ50
DogA0A8I3PWH6
Alternative Names
E2-F1; L-UBC; UBCH7; UbcM4
Function
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Biological Process
Biological Process cell cycle phase transition Source:UniProtKB1 Publication
Biological Process cell population proliferation Source:UniProtKB1 Publication
Biological Process cellular response to glucocorticoid stimulus Source:UniProtKB1 Publication
Biological Process cellular response to steroid hormone stimulus Source:UniProtKB1 Publication
Biological Process positive regulation of protein targeting to mitochondrion Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of protein ubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of ubiquitin-protein transferase activity Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K11-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:UniProtKB2 Publications
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
PTM
Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro (PubMed:22496338).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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