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Mouse Anti-ULBP3 Recombinant Antibody (11D74) (CBMAB-C4593-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
11D74
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
BaF3 cells transfected with human ULBP-3 (hULBP-3)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Saline, 0.5% BSA
Preservative
0.09% Sodium azide
Concentration
0.05 mg/mL

Target

Full Name
UL16 Binding Protein 3
Introduction
The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]
Entrez Gene ID
79465
UniProt ID
Q9BZM4
Alternative Names
UL16 Binding Protein 3; Retinoic Acid Early Transcript 1N; NKG2D Ligand 3; ALCAN-Gamma; NKG2DL3; N2DL-3; RAET1N; UL16-Binding Protein 3; N2DL3;
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Biological Process
Biological Process natural killer cell activation Source:UniProtKB1 Publication
Biological Process natural killer cell mediated cytotoxicity Source:UniProtKB1 Publication
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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