Cynomolgus Recombinant ACVR2B protein, hFc Tag (V2LY-0526-LY1366)

Name: Cynomolgus Recombinant ACVR2B protein, hFc Tag
SKU: V2LY-0526-LY1366
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

hFc Tag

Protein Construction

This product is Cynomolgus Recombinant ACVR2B protein, hFc Tag consist of Amino Acid: 28-143 and predicts a molecular mass of 40.3 kDa.

Molecule Mass

40.3 kDa

Sequence

Amino Acid: 28-143

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

activin A receptor, type IIB

Function

Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

Biological Process

Activin receptor signaling pathway
Anterior/posterior pattern specification
Artery development
Blood vessel remodeling
BMP signaling pathway
Cellular response to growth factor stimulus
Lymphangiogenesis
Lymphatic endothelial cell differentiation
Negative regulation of BMP signaling pathway
Negative regulation of cold-induced thermogenesis
Negative regulation of transcription by RNA polymerase II
Positive regulation of activin receptor signaling pathway
Positive regulation of BMP signaling pathway
Positive regulation of bone mineralization
Positive regulation of osteoblast differentiation
Protein phosphorylation
Regulation of transcription, DNA-templated
Retina vasculature development in camera-type eye
Signal transduction
Transmembrane receptor protein serine/threonine kinase signaling pathway
Venous blood vessel development

Cellular Location

Cell membrane

Involvement in disease

Heterotaxy, visceral, 4, autosomal (HTX4): A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations. HTX4 clinical features include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.

Topology

Extracellular: 19-137 aa
Helical: 138-158 aa
Cytoplasmic: 159-512 aa

PTM

Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity.

O'Sullivan, M. P., Denihan, N., Sikora, K., Finder, M., Ahearne, C., Clarke, G., ... & Murray, D. M. (2021). Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic–Ischemic Encephalopathy. Neuropediatrics.

Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brûlé, E., ... & Bernard, D. J. (2020). Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B. Endocrinology, 161(7).

Bhattacharya, T. K., Shukla, R., Chatterjee, R. N., & Bhanja, S. K. (2019). Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Scientific reports, 9(1), 1-13.

Lautaoja, J. H., Lalowski, M., Nissinen, T. A., Hentilä, J., Shi, Y., Ritvos, O., ... & Hulmi, J. J. (2019). Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade. American Journal of Physiology-Endocrinology And Metabolism, 316(5), E852-E865.

O’Connell, T. M., Pin, F., Couch, M. E., & Bonetto, A. (2019). Treatment with soluble activin receptor type IIB alters metabolic response in chemotherapy-induced cachexia. Cancers, 11(9), 1222.

Gao, X., Zhao, P., Hu, J., Zhu, H., Zhang, J., Zhou, Z., ... & Tang, F. (2018). Micro RNA‐194 protects against chronic hepatitis B‐related liver damage by promoting hepatocyte growth via ACVR 2B. Journal of cellular and molecular medicine, 22(9), 4534-4544.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant ACVR2B protein (CAT#: V2LY-0526-LY1365)

Cynomolgus Recombinant ACVR2B protein, His Tag (CAT#: V2LY-0526-LY1367)

Human Recombinant ACVR2B protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1925)

Human Recombinant ACVR2B protein, ECD, hFc Tag-1 (CAT#: V2LY-0526-LY1926)

Human Recombinant ACVR2B, Active protein, GST Tag (CAT#: V2LY-0526-LY1927)

Human Recombinant ACVR2B protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1928)

Human Recombinant ACVR2B protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY1929)

Human Recombinant ACVR2B protein, His Tag (CAT#: V2LY-0526-LY1930)

Human Recombinant ACVR2B protein, TST & TRX & TEV Tag (CAT#: V2LY-0526-LY1931)

Mouse Recombinant ACVR2B protein, His & hFc Tag (CAT#: V2LY-0526-LY7778)

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Human Recombinant ACVR2B protein, TST & TRX & TEV Tag (CAT#: V2LY-0526-LY1931)

Human Recombinant ACVR2B protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY1929)

Human Recombinant ACVR2B protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1925)

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Human Recombinant ACVR2B, Active protein, GST Tag (CAT#: V2LY-0526-LY1927)

Mouse Recombinant ACVR2B protein, His Tag (CAT#: V2LY-0526-LY7779)

Cynomolgus Recombinant ACVR2B protein (CAT#: V2LY-0526-LY1365)

Human Recombinant ACVR2B protein, ECD, hFc Tag-1 (CAT#: V2LY-0526-LY1926)

Isotype control

For research use only. Not intended for any clinical use.

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