Human Recombinant Ros1 (G2032R), Active protein, GST Tag (V2LY-0526-LY6597)

Name: Human Recombinant Ros1 (G2032R), Active protein, GST Tag
SKU: V2LY-0526-LY6597
Rating: 5 (1 reviews)

See all Ros1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant Ros1 (G2032R), Active protein, GST Tag consist of Amino Acid: 1881-end (G2032R) and predicts a molecular mass of 82 kDa.

Molecule Mass

82 kDa

Sequence

Amino Acid: 1881-end (G2032R)

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

ROS Proto-Oncogene 1, Receptor Tyrosine Kinase

Function

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Biological Process

Biological Process cell differentiationISS:UniProtKB
Biological Process columnar/cuboidal epithelial cell developmentISS:UniProtKB
Biological Process positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spermatogenesisISS:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells.

Topology

Extracellular: 28-1859
Helical: 1860-1882
Cytoplasmic: 1883-2347

PTM

Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity).
Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity).
Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant Ros1 (G2032R), Active protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant Ros1 (F2004C), Active protein, GST Tag (CAT#: V2LY-0526-LY6595)

Human Recombinant Ros1 (F2004I), Active protein, GST Tag (CAT#: V2LY-0526-LY6596)

Human Recombinant Ros1 (G2101A), Active protein, GST Tag (CAT#: V2LY-0526-LY6598)

Human Recombinant Ros1 (G2101C), Active protein, GST Tag (CAT#: V2LY-0526-LY6599)

Human Recombinant Ros1, Active protein, GST Tag (CAT#: V2LY-0526-LY6600)

Human Recombinant Ros1, Active protein, GST Tag-1 (CAT#: V2LY-0526-LY6601)

Human Recombinant Ros1 (L2086F), Active protein, GST Tag (CAT#: V2LY-0526-LY6602)

Related Products

Human Recombinant Ros1 (F2004I), Active protein, GST Tag (CAT#: V2LY-0526-LY6596)

Human Recombinant Ros1, Active protein, GST Tag (CAT#: V2LY-0526-LY6600)

Human Recombinant Ros1 (F2004C), Active protein, GST Tag (CAT#: V2LY-0526-LY6595)

Mouse Anti-ROS1 Recombinant Antibody (2A1) (CAT#: CBMAB-R3229-CN)

Mouse Anti-ROS1 Recombinant Antibody (1A1) (CAT#: CBMAB-R3223-CN)

Mouse Anti-ROS1 Recombinant Antibody (1F4) (CAT#: CBMAB-R3227-CN)

Mouse Anti-ROS1 Recombinant Antibody (69D6) (CAT#: CBMAB-R3243-CN)

Mouse Anti-ROS1 Recombinant Antibody (5D2) (CAT#: CBMAB-R3242-CN)

Human Recombinant Ros1 (G2101A), Active protein, GST Tag (CAT#: V2LY-0526-LY6598)

Mouse Anti-ROS1 Recombinant Antibody (8D2) (CAT#: CBMAB-R3245-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry